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Express Scripts Holding Company (ESRX) Stock Analysis

DELISTED 2018

What happened to Express Scripts Holding Company (ESRX) stock?

Express Scripts Holding Company (ESRX) no longer trades on public markets. It was delisted in December 2018. The figures below are historical and are not a current quote.

P/E Ratio: 11.9|
Data from FMP · Methodology

For informational purposes only. Not financial advice. Analysis by Sedat ANAK, Founder & Editor-in-Chief | AI-powered analysis. Data sourced from SEC filings and institutional-grade financial providers. Editorially reviewed. Not financial advice.

Express Scripts Holding Company (ESRX) trades at $92.33. Express Scripts Holding Company, a subsidiary of Cigna, is a pharmacy benefit management (PBM) organization. It provides integrated pharmacy services, including claims processing and specialty pharmacy solutions. Sector: Healthcare.

Last analyzed: Mar 16, 2026
Express Scripts Holding Company, a subsidiary of Cigna, is a pharmacy benefit management (PBM) organization. It provides integrated pharmacy services, including claims processing and specialty pharmacy solutions.

Analyst Coverage for ESRX: ESRX does not currently have published analyst price targets in our coverage universe. This is common for smaller-cap names with limited Wall Street coverage. In the absence of analyst consensus, our AI model evaluates ESRX against Healthcare peers across nine fundamental dimensions and assigns a neutral fundamental signal based on the underlying data.

Watch the ESRX film Every key number, told as a short cinematic story — just press play. ~2 min
Council Score · Weighted Average of 3 Disciplines
Split View 54/100 · B

ESRX: 1/2 scored disciplines lean bullish. Dominant signal: Ray Dalio bullish.

How is this calculated? →
Legends Council · 5 Legends + Moon AI
Ray Dalio
Bullish
Jim Simons
Neutral
Izzy Englander
Neutral
Seth Klarman
Neutral
Moon AI
Bullish
Munger's Mindset · Balance Sheet & Valuation
Financial Health
Neutral
Margin of Safety
Undervalued
Council Score · Weighted Average of 3 Disciplines · See tabs for details →

Express Scripts Holding Company (ESRX) Healthcare & Pipeline Overview

IPO Year1992

Express Scripts, a subsidiary of Cigna, is a leading pharmacy benefit management (PBM) organization optimizing drug costs and improving patient outcomes. The company offers integrated pharmacy services, including claims processing, home delivery, and specialty pharmacy solutions through Accredo, serving health plans, employers, and government entities in a competitive healthcare landscape.

Data Provenance | Financial Data Quantitative Analysis Analysis: Mar 16, 2026

What Is the Investment Thesis for ESRX?

As of Mar 16, 2026 — figures reflect the data available on that date.

Express Scripts, as a subsidiary of Cigna, benefits from the stability and resources of its parent company. The company's P/E ratio of 11.9 suggests a potentially undervalued position relative to its earnings. A profit margin of 4.5% and a gross margin of 8.8% indicate areas for potential improvement in operational efficiency. Growth catalysts include expanding specialty pharmacy services through Accredo and leveraging data analytics to optimize drug utilization. However, the company faces potential risks from increasing competition in the PBM market and regulatory changes affecting drug pricing and reimbursement. Investors should monitor Cigna's overall strategy and integration efforts to assess the long-term value creation from the Express Scripts acquisition.

Based on FMP financials and quantitative analysis

ESRX Key Highlights

Express Scripts operates as a subsidiary of Cigna following a $54 billion acquisition in December 2018, providing stability and resources.

  • The company's P/E ratio is 11.9, suggesting a potentially undervalued position.
  • Profit margin is 4.5%, indicating an area for potential improvement in operational efficiency.
  • Gross margin is 8.8%, reflecting the difference between revenue and cost of goods sold.
  • The company offers specialty pharmacy services through Accredo, focusing on medications for complex and chronic conditions.

Who Are ESRX's Competitors?

ESRX is benchmarked below against 8 industry peers on price, market cap, and our AI MoonshotScore.

Company Price Change Market Cap AI Score
CVS CVS Health Corporation $93.65 -1.33% $119B 70
UNH UnitedHealth Group Incorporated $387.34 -0.33% $352B 76
ONC BeOne Medicines Ltd. $376.86 +2.09% $40.3B 97
WBA Walgreens Boots Alliance operates as a pharmacy-led health and beauty retail company with a global presence. The company $11.98 +0.50% $10.4B 45
RGEDF Gedeon Richter PLC $41.72 -0.74% $7.63B 53
ALBBY Alibaba Health Information Technology Limited $8.88 +0.00% $7.16B 46
ALBHF Alibaba Health Information Technology Limited $0.44 +0.00% $7.12B 45
RADLY Raia Drogasil S.A. $3.39 +4.31% $5.93B 49

AI Score by Stock Expert AI · Price data: FMP / Yahoo Finance

What Are ESRX's Key Strengths?

Part of Cigna, providing financial stability and resources.

  • Comprehensive suite of pharmacy benefit management services.
  • Specialty pharmacy expertise through Accredo.
  • Data-driven insights for optimizing drug utilization.

What Are ESRX's Weaknesses?

Relatively low profit margin of 4.5%.

  • Gross margin of 8.8% is lower than some competitors.
  • Dependence on Cigna's overall strategy and performance.
  • Potential for conflicts of interest as part of a larger healthcare organization.

What Could Drive ESRX Stock Higher?

Expansion of Accredo's specialty pharmacy services, driving revenue growth and market share.

  • Leveraging data analytics to improve medication adherence and patient outcomes.
  • Integration with Cigna's broader healthcare offerings, creating synergies and cross-selling opportunities.
  • Potential for new partnerships with healthcare providers to expand service offerings.

What Are the Key Risks for ESRX?

Insider selling — insiders were net sellers of roughly $68.4M recently.

  • Increasing competition in the PBM market, leading to pricing pressure and margin erosion.
  • Regulatory changes affecting drug pricing and reimbursement, impacting revenue and profitability.
  • Consolidation among healthcare providers and insurers, reducing bargaining power.
  • Disruptive technologies and new entrants challenging the traditional PBM model.
  • Dependence on Cigna's overall performance and strategic direction.

What Are the Growth Opportunities for ESRX?

  • Expansion of Specialty Pharmacy Services: Accredo, Express Scripts' specialty pharmacy, presents a significant growth opportunity. The market for specialty drugs, which treat complex and chronic conditions, is projected to reach $400 billion by 2026. By expanding Accredo's services and capabilities, Express Scripts can capture a larger share of this growing market. This includes developing specialized programs for specific disease states and enhancing patient support services to improve adherence and outcomes.
  • Leveraging Data Analytics for Personalized Healthcare: Express Scripts can leverage its extensive data on drug utilization and patient outcomes to develop personalized healthcare solutions. By analyzing this data, the company can identify patterns and trends that inform targeted interventions and improve medication adherence. The market for personalized medicine is expected to reach $2.4 trillion by 2026. This includes developing predictive models to identify patients at risk for adverse drug events and tailoring medication regimens to individual patient needs.
  • Strategic Partnerships with Healthcare Providers: Forming strategic partnerships with healthcare providers, such as hospitals and physician groups, can create new growth opportunities for Express Scripts. By integrating pharmacy services with medical care, the company can improve care coordination and reduce healthcare costs. The market for integrated healthcare services is projected to reach $300 billion by 2026. This includes developing collaborative care models that involve pharmacists in medication management and patient education.
  • Expansion of Home Delivery Pharmacy Services: Expanding home delivery pharmacy services can drive growth by offering convenience and cost savings to patients. Home delivery pharmacies can offer lower prices and improved adherence compared to traditional retail pharmacies. The market for online pharmacies is expected to reach $200 billion by 2026. This includes investing in technology and infrastructure to support efficient and reliable home delivery services.
  • Development of Innovative Pharmacy Benefit Programs: Developing innovative pharmacy benefit programs can attract new clients and retain existing ones. This includes programs that focus on value-based care, medication adherence, and chronic disease management. The market for innovative healthcare solutions is projected to reach $150 billion by 2026. This includes developing programs that reward patients for adhering to their medication regimens and achieving specific health outcomes.

What Are ESRX's Competitive Advantages?

  • Scale: Benefits from its large scale and market share in the PBM industry.
  • Integrated Services: Offers a comprehensive suite of pharmacy services, including claims processing, home delivery, and specialty pharmacy.
  • Data Analytics: Leverages data analytics to provide clients with insights into drug utilization and cost trends.
  • Established Relationships: Maintains long-standing relationships with health plans, employers, and pharmaceutical manufacturers.

What Does ESRX Do?

Express Scripts Holding Company, established in 1986, operates as a pharmacy benefit management (PBM) organization. The company provides a range of integrated pharmacy services designed to manage drug costs and improve patient health outcomes. Its services include pharmacy claims processing, which ensures efficient and accurate handling of prescription claims; home delivery pharmacy services, offering convenience and cost savings for patients; and formulary management, which involves creating and managing lists of covered medications to optimize drug utilization and costs. Express Scripts also provides specialty pharmacy services through Accredo, focusing on medications for complex and chronic conditions. Furthermore, the company leverages data-driven drug utilization insights to help clients make informed decisions about their pharmacy benefits programs. Following a $54 billion acquisition by Cigna in December 2018, Express Scripts operates as a subsidiary, enhancing Cigna's healthcare offerings and market position. The integration allows for a more comprehensive approach to healthcare management, combining pharmacy benefits with medical and behavioral health services.

What Products and Services Does ESRX Offer?

  • Pharmacy Claims Processing: Efficiently and accurately processes prescription claims for health plans and employers.
  • Home Delivery Pharmacy: Provides convenient and cost-effective medication delivery services directly to patients.
  • Formulary Management: Develops and manages lists of covered medications to optimize drug utilization and costs.
  • Specialty Pharmacy (Accredo): Offers specialized medications and support services for patients with complex and chronic conditions.
  • Data-Driven Drug Utilization Insights: Leverages data analytics to provide clients with insights into drug utilization patterns and trends.
  • Benefit Design and Consulting: Helps clients design pharmacy benefit programs that meet their specific needs and goals.
  • Medication Therapy Management (MTM): Provides services to help patients manage their medications and improve their health outcomes.

How Does ESRX Make Money?

  • Pharmacy Benefit Management (PBM): Acts as an intermediary between health plans, employers, and pharmaceutical manufacturers to manage prescription drug benefits.
  • Claims Processing Fees: Generates revenue from processing prescription claims for health plans and employers.
  • Rebates from Pharmaceutical Manufacturers: Receives rebates from pharmaceutical manufacturers in exchange for including their drugs on formularies.
  • Mail-Order Pharmacy: Earns revenue from dispensing medications through its home delivery pharmacy services.

What Industry Does ESRX Operate In?

Express Scripts operates within the pharmacy benefit management (PBM) industry, a sector characterized by intense competition and evolving regulatory landscapes. PBMs play a crucial role in managing prescription drug costs for health plans, employers, and government entities. The industry is influenced by factors such as drug pricing trends, biosimilar adoption, and legislative efforts to control healthcare spending. Express Scripts competes with other major PBMs, such as CVS Caremark and OptumRx, in a market driven by scale, service offerings, and data analytics capabilities. The increasing demand for specialty medications and personalized healthcare solutions presents both opportunities and challenges for PBMs.

Who Are ESRX's Key Customers?

  • Health Plans: Provides pharmacy benefit management services to health insurance companies.
  • Employers: Offers pharmacy benefit programs to employers for their employees.
  • Government Entities: Manages pharmacy benefits for government-sponsored healthcare programs.
  • Patients: Provides medications and pharmacy services directly to patients through its home delivery and specialty pharmacies.
AI Confidence: 73% Updated: Mar 16, 2026

Company Profile

Express Scripts Holding Company operates in the Medical - Pharmaceuticals industry within the Healthcare sector. ESRX has traded publicly since 1992.

ROE 26%

Key Financial Metrics

Return on equity for Express Scripts Holding Company stands at 26.3%, a gauge of how efficiently it converts shareholder capital into profit. Return on assets is 8.3%, showing how much profit it generates from its asset base. ESRX trades at a trailing price-to-earnings ratio of 11.86, below the Healthcare sector average of ~23x. A current ratio of 0.67 means current liabilities exceed short-term assets, a liquidity point worth watching. Its earnings yield is 8.4%, the inverse of the P/E and a quick read on earnings relative to price.

Net selling

Insider Activity

The most recent 12 insider filings for Express Scripts Holding Company break down as 11 sales and 1 purchases. On net that is roughly 1.1M shares disposed (about $68.4M), a signal worth weighing alongside the fundamentals.

ESRX Financials

Fundamental Snapshot

P/E (TTM)
11.9
Return on Equity (TTM)
+26.3%
Current Ratio
0.7
EV/EBITDA (TTM)
1.9

Based on FMP financials and quantitative analysis

Bull Case vs Bear Case

Bull Case

  • Part of Cigna, providing financial stability and resources.
  • Comprehensive suite of pharmacy benefit management services.
  • Specialty pharmacy expertise through Accredo.
  • Data-driven insights for optimizing drug utilization.

Bear Case

  • Relatively low profit margin of 4.5%.
  • Gross margin of 8.8% is lower than some competitors.
  • Dependence on Cigna's overall strategy and performance.
  • Potential for conflicts of interest as part of a larger healthcare organization.

AI-generated arguments based on insider flow, news sentiment and technicals — not financial advice · August 2026

ESRX Latest News

ESRX Healthcare Stock FAQ

What happened to Express Scripts Holding Company (ESRX) stock?

Express Scripts Holding Company (ESRX) no longer trades on public markets. It was delisted in December 2018. The figures below are historical and are not a current quote.

Can I still buy ESRX shares?

No. ESRX stopped trading on public markets in December 2018, so the shares are not available through a broker. Anything you see quoted for ESRX elsewhere is historical data, not a live market.

Are the figures on this page current?

No. Every number here is the last value recorded before ESRX stopped trading. Nothing on this page updates, and none of it is a current quote.

Why does this page still exist?

Because people still search for what happened to Express Scripts Holding Company. An archived profile that states the delisting plainly is more useful than a dead link — provided it is labelled as history, which is what this page does.

What does Express Scripts Holding Company do?

Express Scripts Holding Company operates as a pharmacy benefit management (PBM) organization, providing integrated services to manage prescription drug benefits for health plans, employers, and government entities. The company's services include pharmacy claims processing, home delivery pharmacy, formulary management, and specialty pharmacy through Accredo.

What do analysts say about ESRX stock?

As Express Scripts Holding Company is a subsidiary of Cigna (CI), analyst coverage is primarily focused on Cigna's overall performance and strategy. Analysts generally view the acquisition of Express Scripts as a strategic move that enhances Cigna's healthcare offerings and market position.

What are the main risks for ESRX?

Express Scripts faces several risks inherent to the pharmacy benefit management (PBM) industry. Increasing competition among PBMs can lead to pricing pressure and margin erosion. Regulatory changes affecting drug pricing and reimbursement, such as government efforts to lower drug costs, can impact revenue and profitability. Consolidation among healthcare providers and insurers can reduce Express Scripts' bargaining power.

Disclaimer: This content is for informational purposes only and does not constitute investment advice. Always do your own research and consult a financial advisor.

Official Resources

Analysis updated
Data Sources & Methodology
Market data powered by Financial Modeling Prep & Yahoo Finance. AI analysis by Stock Expert AI proprietary algorithms. Technical indicators via industry-standard calculations. Last updated: .
Data Provenance
Sources: Financial Modeling Prep (FMP) — Primary · Yahoo Finance — Fallback · Alpaca — Tertiary
Last fetched:
Cache TTL: Quote 5min · Profile 7d · Financials 7d · Insider 48h
How we use AI: Numbers are pulled directly from FMP & Yahoo Finance — our AI writes the analysis, it never edits the figures.
Data provided as-is for educational purposes. Not financial advice. Methodology

Data provided for informational purposes only.

Analysis Notes
  • Information is based on available data and may be subject to change.
  • AI analysis is pending and may provide additional insights.
Data Sources

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