Achilles Therapeutics plc (ACHL)
For informational purposes only. Not financial advice. Analysis by Sedat ANAK, Founder & Editor-in-Chief | AI-powered analysis. Data sourced from SEC filings and institutional-grade financial providers. Editorially reviewed. Not financial advice.
Achilles Therapeutics plc (ACHL) trades at $1.48 with AI Score 47/100 (Grade C). Achilles Therapeutics plc is a clinical-stage immuno-oncology company focused on developing precision T cell therapies for solid tumors. Market cap: $60.83M, Sector: Healthcare.
Price live · AI analysis from Mar 16, 2026Analyst Coverage for ACHL: ACHL does not currently have published analyst price targets in our coverage universe. This is common for smaller-cap names with limited Wall Street coverage. In the absence of analyst consensus, our AI model evaluates ACHL against Healthcare peers across nine fundamental dimensions and assigns an underweight signal based on the underlying data.
ACHL: the 1 perspectives are evenly split.
How is this calculated? →Achilles Therapeutics plc (ACHL) Healthcare & Pipeline Overview
Achilles Therapeutics plc, a clinical-stage immuno-oncology company, pioneers precision T-cell therapies targeting clonal neoantigens in solid tumors. Their personalized approach, focusing on individualized cancer treatments, positions them within the competitive biotechnology landscape, addressing unmet needs in advanced non-small cell lung cancer and metastatic melanoma.
What Is the Investment Thesis for ACHL?
Achilles Therapeutics presents a high-risk, high-reward investment opportunity within the immuno-oncology space. The company's focus on personalized T-cell therapies targeting clonal neoantigens offers a novel approach to treating solid tumors. Key value drivers include positive clinical trial data from the CHIRON and THETIS trials, which could lead to accelerated regulatory pathways. Growth catalysts include expansion into additional solid tumor indications and potential partnerships with larger pharmaceutical companies. However, the company faces significant risks, including clinical trial failures, regulatory hurdles, and competition from established players in the immunotherapy market. With a market cap of $60.83M and a negative P/E ratio of -0.85, Achilles Therapeutics' valuation is highly dependent on successful clinical development and future commercialization of its therapies.
Based on FMP financials and quantitative analysis
ACHL Key Highlights
- Achilles Therapeutics is currently running Phase I/IIa clinical trials for CHIRON in advanced non-small cell lung cancer.
- Achilles Therapeutics is currently running Phase I/IIa clinical trials for THETIS in metastatic or recurrent melanoma.
- The company was founded in 2016, indicating it is still in the early stages of its development.
- Achilles Therapeutics changed its name from Achilles TX Limited in February 2021.
- The company has 204 employees, reflecting its scale as a clinical-stage biopharmaceutical company.
Who Are ACHL's Competitors?
ACHL is benchmarked below against 8 industry peers on price, market cap, and our AI MoonshotScore.
| Company | Price | Change | Market Cap | AI Score |
|---|---|---|---|---|
| ALVR AlloVir, Inc. | $9.81 | +4.14% | $49.48M | 46 |
| HTBX Heat Biologics, Inc. | $2.38 | +0.42% | $61.07M | 48 |
| KRON Kronos Bio, Inc. | $0.88 | +1.49% | $53.65M | 65 |
| RNTX Rein Therapeutics, Inc. | $1.01 | +2.37% | $28.38M | — |
| SNDX Syndax Pharmaceuticals, Inc. | $22.11 | +1.33% | $1.96B | 79 |
| ANAB AnaptysBio, Inc. | $63.69 | +0.43% | $2.75B | 79 |
| ABVX Abivax S.A. | $145.38 | +0.51% | $9.53B | 76 |
| CGEN Compugen Ltd. | $2.37 | +3.73% | $223.62M | 76 |
AI Score by Stock Expert AI · Price data: FMP / Yahoo Finance
What Are ACHL's Key Strengths?
- Proprietary technology for targeting clonal neoantigens.
- Personalized approach to T cell therapy development.
- Strong intellectual property portfolio.
- Experienced management team.
What Are ACHL's Weaknesses?
- Clinical-stage company with no approved products.
- High cash burn rate.
- Reliance on successful clinical trial outcomes.
- Limited manufacturing capacity.
What Could Drive ACHL Stock Higher?
- Interim data readout from the CHIRON Phase I/IIa clinical trial for advanced NSCLC (H2 2026).
- Interim data readout from the THETIS Phase I/IIa clinical trial for metastatic or recurrent melanoma (H2 2026).
- Enrollment and patient recruitment in ongoing clinical trials.
- Announcement of strategic partnerships or collaborations with larger pharmaceutical companies (2026-2027).
What Are the Key Risks for ACHL?
- Financial-distress signal — its Altman Z-Score of -2.67 sits in the distress zone (elevated bankruptcy risk).
- Negative return on equity (-41.1%) — the business is not currently generating profit on shareholder capital.
- Weak fundamentals — a Piotroski F-Score of 1/9 flags soft profitability, leverage or efficiency.
- Clinical trial failures or delays.
- Regulatory hurdles and delays in obtaining approvals.
- Competition from established players in the immunotherapy market.
- High cash burn rate and the need for additional financing.
- Negative impact from economic downturn and reduced healthcare spending.
What Are the Growth Opportunities for ACHL?
- Expansion into Additional Solid Tumor Indications: Achilles Therapeutics has the opportunity to expand its personalized T-cell therapy platform into additional solid tumor indications beyond NSCLC and melanoma, such as head and neck squamous cell carcinoma, renal cell carcinoma, triple-negative breast cancer, and bladder cancer. Each of these indications represents a significant market opportunity, with a combined market size estimated at billions of dollars. Success in these areas would significantly increase the company's revenue potential and market share. This expansion is expected to occur over the next 3-5 years, contingent on positive clinical trial data.
- Strategic Partnerships with Larger Pharmaceutical Companies: Achilles Therapeutics could pursue strategic partnerships with larger pharmaceutical companies to accelerate the development and commercialization of its therapies. These partnerships could provide access to additional funding, expertise, and resources, as well as a broader distribution network. The potential for such partnerships is high, given the increasing interest in personalized cancer immunotherapies. These partnerships could materialize within the next 2-3 years, depending on clinical trial progress and market demand.
- Advancements in Manufacturing and Scalability: Improving the manufacturing process and scalability of its personalized T-cell therapies is crucial for Achilles Therapeutics to meet future demand and reduce costs. Investing in advanced manufacturing technologies and streamlining the production process could significantly improve the company's profitability and competitiveness. This is an ongoing process, with continuous improvements expected over the next several years.
- Securing Regulatory Approvals and Market Access: Obtaining regulatory approvals from the FDA and other regulatory agencies is essential for Achilles Therapeutics to commercialize its therapies and generate revenue. Successfully navigating the regulatory landscape and securing market access in key markets, such as the United States and Europe, will be critical for the company's long-term success. Regulatory decisions are expected within the next 2-4 years, following the completion of clinical trials.
- Development of Next-Generation T-Cell Therapies: Achilles Therapeutics can invest in the development of next-generation T-cell therapies with enhanced efficacy and safety profiles. This could involve incorporating new technologies, such as gene editing or novel targeting strategies, to improve the performance of its therapies. This research and development effort is expected to yield results over the next 5-7 years, leading to the development of more advanced and effective cancer treatments.
What Opportunities Does ACHL Have?
- Expansion into additional solid tumor indications.
- Strategic partnerships with larger pharmaceutical companies.
- Advancements in manufacturing and scalability.
- Securing regulatory approvals and market access.
What Threats Does ACHL Face?
- Clinical trial failures.
- Regulatory hurdles.
- Competition from established players in the immunotherapy market.
- Economic downturn and reduced healthcare spending.
What Are ACHL's Competitive Advantages?
- Proprietary technology for identifying and targeting clonal neoantigens.
- Personalized approach to T cell therapy development.
- Strong intellectual property portfolio protecting its technology and products.
What Does ACHL Do?
Achilles Therapeutics plc, founded in 2016 and headquartered in London, is a clinical-stage immuno-oncology biopharmaceutical company focused on developing precision T cell therapies for the treatment of solid tumors. The company's approach centers on targeting clonal neoantigens, unique markers present on cancer cells, to create personalized immunotherapies. Their lead product candidates include CHIRON, currently in Phase I/IIa clinical trials for advanced non-small cell lung cancer (NSCLC), and THETIS, also in Phase I/IIa trials for metastatic or recurrent melanoma. These trials aim to assess the safety and efficacy of Achilles' personalized T cell therapies in patients with advanced cancers. Beyond NSCLC and melanoma, Achilles is also developing products targeting other solid tumors, including head and neck squamous cell carcinoma, renal cell carcinoma, triple-negative breast cancer, and bladder cancer. The company's evolution from Achilles TX Limited to Achilles Therapeutics Plc in February 2021 reflects its commitment to advancing its pipeline of personalized cancer immunotherapies. Achilles Therapeutics operates with 204 employees, focusing on research, development, and clinical trials to bring innovative treatments to patients with significant unmet medical needs.
What Products and Services Does ACHL Offer?
- Develops personalized T cell therapies for solid tumors.
- Targets clonal neoantigens, unique markers on cancer cells.
- Conducts Phase I/IIa clinical trials for advanced non-small cell lung cancer (NSCLC).
- Conducts Phase I/IIa clinical trials for metastatic or recurrent melanoma.
- Develops products for head and neck squamous cell carcinoma.
- Develops products for renal cell carcinoma.
- Develops products for triple-negative breast cancer.
- Develops products for bladder cancer.
How Does ACHL Make Money?
- Develops precision T cell therapies in-house.
- Outlicenses or partners with larger pharmaceutical companies for commercialization.
- Generates revenue through milestone payments and royalties on sales of approved therapies.
What Industry Does ACHL Operate In?
Achilles Therapeutics operates within the rapidly evolving immuno-oncology market, which is projected to reach $79.4 billion by 2028. The industry is characterized by intense competition, with numerous companies developing novel immunotherapies, including checkpoint inhibitors, CAR-T cell therapies, and cancer vaccines. Achilles' focus on personalized T-cell therapies targeting clonal neoantigens differentiates it from competitors, offering the potential for more precise and effective cancer treatments. The company's success depends on its ability to navigate the complex regulatory landscape, secure funding, and demonstrate clinical efficacy in its ongoing trials.
Who Are ACHL's Key Customers?
- Patients with advanced solid tumors, including NSCLC and melanoma.
- Oncologists and other healthcare professionals who treat cancer patients.
- Hospitals and cancer centers that administer T cell therapies.
FY2026 estForward Outlook
Wall Street analysts project Achilles Therapeutics plc revenue of about $0 for fiscal 2026, with EPS near $-1.22.
F-Score 1/9Financial Health
Achilles Therapeutics plc's Piotroski F-Score is 1/9, a 9-point checklist of profitability, leverage and efficiency — flagging fundamental weakness worth scrutiny. Its Altman Z-Score of -2.67 places it in the distress zone, a signal of elevated financial risk.
ROE -41%Key Financial Metrics
Return on equity for Achilles Therapeutics plc stands at -41.1%, a gauge of how efficiently it converts shareholder capital into profit. Return on assets is -43.1%, showing how much profit it generates from its asset base. Its free cash flow yield is -81.5%, a gauge of the cash the business throws off relative to its market value. A current ratio of 8.57 indicates the company holds enough short-term assets to cover its near-term obligations. Its earnings yield is -117.8%, the inverse of the P/E and a quick read on earnings relative to price.
Achilles Therapeutics plc (ACHL) Valuation Context
Valued at $60.83M, ACHL is classified as a micro-cap stock. Relative to its peer group, ACHL's quantitative score of 47/100 is below the peer average of 60/100.
Company Profile
Achilles Therapeutics plc operates in the Biotechnology industry within the Healthcare sector. It is headquartered in London, GB. The company is led by CEO Iraj Ali. ACHL has traded publicly since 2021.
ACHL Financials
Fundamental Snapshot
Based on FMP financials and quantitative analysis
Bull Case vs Bear Case
Bull Case
- Proprietary technology for targeting clonal neoantigens.
- Personalized approach to T cell therapy development.
- Strong intellectual property portfolio.
- Experienced management team.
Bear Case
- Clinical-stage company with no approved products.
- High cash burn rate.
- Reliance on successful clinical trial outcomes.
- Limited manufacturing capacity.
AI-generated arguments based on insider flow, news sentiment and technicals — not financial advice · July 2026
ACHL Latest News
No recent news available for ACHL.
ACHL Analyst Consensus
Consensus Rating
Aggregated Buy/Hold/Sell recommendations from Benzinga, Yahoo Finance, and Finnhub for ACHL.
Price Targets
Wall Street price target analysis for ACHL.
ACHL MoonshotScore
What does this score mean?
The MoonshotScore rates ACHL's growth potential on a scale of 0-100 across multiple factors including innovation, market disruption, financial health, and momentum.
Leadership: Iraj Ali
CEO
Iraj Ali serves as the CEO of Achilles Therapeutics plc. His background includes extensive experience in the biopharmaceutical industry, with a focus on oncology and immunotherapy. Prior to joining Achilles, he held leadership positions at several biotech companies, where he was responsible for driving the development and commercialization of innovative therapies. He has a strong track record of building and managing high-performing teams and successfully navigating the complex regulatory landscape.
Track Record: Since becoming CEO, Iraj Ali has overseen the advancement of Achilles' lead product candidates, CHIRON and THETIS, through Phase I/IIa clinical trials. He has also been instrumental in securing funding and establishing strategic partnerships to support the company's growth. His leadership has been focused on building a strong scientific team and advancing the company's personalized T cell therapy platform.
Achilles Therapeutics plc ADR Information Sponsored
An American Depositary Receipt (ADR) is a certificate representing shares of a foreign company, allowing U.S. investors to trade the shares on U.S. stock exchanges. For Achilles Therapeutics (ACHL), as an ADR, it represents ordinary shares of the company traded on its home market, enabling U.S. investors to invest in Achilles without dealing with foreign exchanges.
- Home Market Ticker: London Stock Exchange, United Kingdom
- ADR Level: 2
- ADR Ratio: 1:1
Common Questions About ACHL (Healthcare)
What does Achilles Therapeutics plc do?
Achilles Therapeutics plc is a clinical-stage immuno-oncology company focused on developing personalized T cell therapies for solid tumors. The company's approach centers on targeting clonal neoantigens, unique markers present on cancer cells, to create individualized immunotherapies. Their lead product candidates, CHIRON and THETIS, are currently in Phase I/IIa clinical trials for advanced non-small cell lung cancer and metastatic melanoma, respectively. Achilles aims to provide more precise and effective cancer treatments by leveraging the patient's own immune system to target and destroy cancer cells.
What do analysts say about ACHL stock?
Analyst coverage of Achilles Therapeutics is limited, reflecting its status as a clinical-stage company. Current analyst consensus is Unknown, with valuations highly dependent on clinical trial outcomes and future commercialization potential. Key valuation metrics include potential peak sales of its lead product candidates and the probability of regulatory approval. Growth considerations include expansion into additional solid tumor indications and potential partnerships. Investors should conduct their own due diligence and consider the inherent risks associated with investing in early-stage biotechnology companies.
What are the main risks for ACHL?
Achilles Therapeutics faces several key risks, including the potential for clinical trial failures or delays, which could significantly impact its valuation and future prospects. Regulatory hurdles and delays in obtaining approvals from the FDA and other regulatory agencies also pose a significant risk. The company operates in a highly competitive market, facing competition from established players in the immunotherapy space. Additionally, Achilles has a high cash burn rate and will likely require additional financing in the future, which could dilute existing shareholders. Economic downturns and reduced healthcare spending could also negatively impact the company's performance.
What are the key factors to evaluate for ACHL?
Achilles Therapeutics plc (ACHL) holds an AI score of 47/100 (low). Not financial advice.
How frequently does ACHL data refresh on this page?
ACHL prices update in real time during U.S. market hours. Fundamentals refresh after quarterly filings; analyst ratings and AI insights update daily; news is aggregated continuously.
What has driven ACHL's recent stock price performance?
Achilles Therapeutics plc (ACHL) moves on earnings results, analyst revisions, sector rotation, and market sentiment. Notable catalyst: Proprietary technology for targeting clonal neoantigens. See the News tab for the latest drivers. Past performance does not predict future results.
Should investors consider ACHL overvalued or undervalued right now?
Valuing Achilles Therapeutics plc (ACHL) requires multiple metrics. Compare P/E, P/S, and EV/EBITDA against sector peers for a full view.
What research should beginners do before buying ACHL?
Before investing in Achilles Therapeutics plc (ACHL), research these four areas: (1) the company's revenue model and competitive position (see Company Overview), (2) financial health through revenue growth, margins, and cash flow (see MoonshotScore), (3) what Wall Street analysts recommend and their price targets (see Analyst tab), and (4) specific risk factors that could impact the stock (see Risk Factors section).
Disclaimer: This content is for informational purposes only and does not constitute investment advice. Always do your own research and consult a financial advisor.
Official Resources
Data provided for informational purposes only.
- AI analysis pending for ACHL. Information is based on limited data available.