Acusphere, Inc. (ACUS) Stock Price & Analysis
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For informational purposes only. Not financial advice. Machine-generated analysis by Stock Expert AI — model gemini-2.5-flash, generated Jun 15, 2026. Editorial oversight is systemic, not page-by-page. Editorially accountable: Sedat ANAK, Founder and Editor-in-Chief. Data sources: Financial Modeling Prep, Yahoo Finance, SEC EDGAR
Quick AnswerAcusphere, Inc. (ACUS) trades at $0.00001. Acusphere, Inc. is a specialty pharmaceutical company focused on developing and commercializing cardiovascular drugs. Its primary product, Imagify, is an injectable suspension used for evaluating myocardial perfusion and detecting coronary artery disease. Sector: Healthcare.
Price as of · Last analyzed: Jun 15, 2026Analyst Coverage for ACUS: ACUS does not currently have published analyst price targets in our coverage universe. This is common for smaller-cap names with limited Wall Street coverage.
No score published: we hold no usable price for this ticker, and a grade beside a missing price says nothing.
Acusphere, Inc. (ACUS) Healthcare & Pipeline Overview
Acusphere, Inc. is a specialty pharmaceutical company based in Watertown, Massachusetts, focused on developing and commercializing cardiovascular drugs. Its primary offering, Imagify (perflubutane polymer microspheres), is an injectable suspension designed to evaluate myocardial perfusion and detect coronary artery disease, addressing a critical diagnostic need within the healthcare sector.
What Is the Investment Thesis for ACUS?
Acusphere, Inc. presents a focused investment profile centered on its sole commercialized product, Imagify (perflubutane polymer microspheres), a specialized cardiovascular diagnostic agent. The core value driver for Acusphere lies in the continued adoption and market penetration of Imagify, which addresses a critical need for evaluating myocardial perfusion and detecting coronary artery disease. The global market for cardiovascular diagnostics remains substantial, driven by the increasing prevalence of heart disease, suggesting an underlying demand for effective diagnostic tools. Potential growth catalysts include expanded clinical utility for Imagify, potentially through new indications or improved diagnostic protocols, and strategic initiatives to enhance its commercial reach. However, the company faces significant challenges, as evidenced by its reported market capitalization of $0.00 billion and a deeply negative profit margin of -2014.6%. These metrics indicate substantial operational losses and a highly constrained financial position. The gross margin of 100.0% suggests that direct cost of goods sold for Imagify is minimal or offset, but this does not translate to overall profitability. The company's beta of -0.52 indicates an inverse relationship with market movements, which can be unusual for a pharmaceutical company. Future value creation is contingent upon a dramatic improvement in commercial performance, effective cost management, and potential capital infusions to sustain operations and drive Imagify's market presence.
Based on FMP financials and quantitative analysis
ACUS Key Highlights
Market Capitalization: $0.00 billion, indicating a minimal or non-existent public market valuation.
- Profit Margin: -2014.6%, reflecting substantial operational losses relative to revenue.
- Gross Margin: 100.0%, suggesting that direct costs associated with Imagify's production or sales are negligible or fully absorbed by other factors, though overall profitability remains deeply negative.
- Beta: -0.52, indicating an inverse correlation with broader market movements, which is an atypical characteristic for a pharmaceutical company.
- Product Focus: Sole commercial product, Imagify, an injectable suspension for cardiovascular diagnostics, highlighting a highly specialized business model.
Who Are ACUS's Competitors?
ACUS is benchmarked below against 8 industry peers on price, market cap, and our AI MoonshotScore.
| Company | Price | Change | Market Cap | MoonshotScore |
|---|---|---|---|---|
| AKAN Akanda Corp. | $1.89 | -4.55% | — | |
| SNOA Sonoma Pharmaceuticals, Inc. | $1.24 | -0.81% | $5.94M | — |
| APUS Apimeds Pharmaceuticals US, Inc. | $4.36 | +35.40% | $7.59M | — |
| BFRI Biofrontera Inc. | $0.91 | -10.34% | $13.0M | — |
| COSM COSM | $0.34 | -9.61% | $20.7M | — |
| QNTM Quantum BioPharma Ltd. | $3.30 | -4.07% | $22.0M | — |
| AYTU Aytu BioPharma, Inc. | $2.10 | +1.45% | $22.2M | — |
| TXMD TherapeuticsMD, Inc. | $2.05 | 0.00% | $23.7M | — |
AI Score by Stock Expert AI · Price data: FMP / Yahoo Finance
What Are ACUS's Key Strengths?
Specialized product (Imagify) addressing a specific diagnostic need in cardiovascular health.
- Established company history since 1993, indicating longevity in the industry.
- 100.0% Gross Margin, suggesting efficient direct cost management for its product.
- Focus on a critical medical area (coronary artery disease detection).
What Are ACUS's Weaknesses?
Market capitalization of $0.00 billion, indicating severe financial distress or lack of public trading value.
- Deeply negative Profit Margin of -2014.6%, highlighting significant ongoing operational losses.
- Single commercialized product (Imagify), leading to high product concentration risk.
- OTC market listing and "OTC Other" tier, implying lower transparency and liquidity compared to major exchanges.
What Are the Key Risks for ACUS?
Financial-distress signal — its Altman Z-Score of -30.04 sits in the distress zone (elevated bankruptcy risk).
- Inconsistent delivery — missed Wall Street EPS estimates in 6 of the last 8 reported quarters.
- Weak fundamentals — a Piotroski F-Score of 3/9 flags soft profitability, leverage or efficiency.
- Deeply negative profit margin of -2014.6% and a market capitalization of $0.00 billion, indicating severe financial distress and potential going concern issues.
- High product concentration risk due to reliance on a single commercialized product, Imagify, making the company vulnerable to market shifts or competitive pressures.
- OTC market listing under the "OTC Other" tier, which implies limited transparency, low liquidity, and heightened investment risk.
- Intense competition from other diagnostic imaging modalities and contrast agents in the cardiovascular market, potentially limiting Imagify's market share.
- Challenges in securing additional funding or capital, which would be critical for sustaining operations and any potential growth initiatives, given current financial metrics.
What Threats Does ACUS Face?
- Intense competition from alternative cardiovascular diagnostic methods and contrast agents.
- Regulatory changes or increased scrutiny impacting the approval or commercialization of diagnostic drugs.
- Dependence on a single product makes the company highly vulnerable to market shifts or product obsolescence.
- Funding challenges and inability to secure capital given the current financial metrics and OTC status.
What Are ACUS's Competitive Advantages?
- Specialized Product: Imagify (perflubutane polymer microspheres) is a unique injectable suspension for specific cardiovascular diagnostic applications.
- Regulatory Approval: Successful navigation of regulatory pathways to bring Imagify to market, representing a significant barrier to entry for new competitors.
- Established Presence: Operating since 1993, the company has a long history in the pharmaceutical development space.
- Niche Focus: Dedicated specialization in cardiovascular diagnostics allows for deep expertise and targeted market penetration.
What Does ACUS Do?
Acusphere, Inc., originally incorporated as Polymers For Medicine, Inc. in 1993, has evolved into a specialty pharmaceutical company dedicated to addressing cardiovascular health needs through innovative drug development and commercialization. The company officially adopted its current name, Acusphere, Inc., in March 2004, marking a strategic shift towards its specialized focus within the pharmaceutical landscape. Headquartered in Watertown, Massachusetts, Acusphere's core business revolves around its flagship product, Imagify (perflubutane polymer microspheres). This cardiovascular drug is specifically designed as an injectable suspension for critical diagnostic applications. Imagify's primary function is to facilitate the evaluation of myocardial perfusion, a key indicator of heart muscle blood flow, and to aid in the detection of coronary artery disease, a prevalent and serious condition affecting millions globally. By providing a specialized diagnostic agent, Acusphere positions itself within the niche market of cardiovascular imaging and diagnostics, offering healthcare professionals a tool to enhance the precise assessment of cardiac function and blood flow. The company's operational model centers on the rigorous development, regulatory approval processes, and subsequent commercialization of such specialized pharmaceutical products. Its long-standing presence since 1993 underscores its commitment to the healthcare sector, specifically within the demanding field of drug manufacturing for specialty and generic applications. Acusphere's strategic focus on a single, specialized product like Imagify highlights its targeted approach to market penetration and its dedication to a specific area of medical need. This specialization allows the company to concentrate its resources on optimizing the utility and market acceptance of Imagify, aiming to provide precise and effective diagnostic solutions for complex cardiovascular conditions. The company's history reflects a journey from a broader polymer focus to a highly specialized pharmaceutical entity, adapting to market demands and scientific advancements in cardiovascular medicine.
What Products and Services Does ACUS Offer?
- Develops and commercializes cardiovascular drugs.
- Offers Imagify (perflubutane polymer microspheres).
- Imagify is an injectable suspension.
- Imagify is used to evaluate myocardial perfusion.
- Imagify aids in detecting coronary artery disease.
- Operates as a specialty pharmaceutical company.
- Founded in 1993, originally as Polymers For Medicine, Inc.
How Does ACUS Make Money?
- Research, develop, and obtain regulatory approval for specialized cardiovascular diagnostic drugs.
- Manufacture and commercialize its flagship product, Imagify (perflubutane polymer microspheres).
- Generate revenue through the sale of Imagify to healthcare providers and institutions.
- Focus on a niche market within cardiovascular diagnostics.
What Industry Does ACUS Operate In?
Acusphere, Inc. operates within the highly specialized and regulated sector of Drug Manufacturers - Specialty & Generic, with a particular focus on cardiovascular drugs. The broader healthcare industry, and specifically the market for cardiovascular diagnostics, is characterized by ongoing innovation, stringent regulatory oversight, and a persistent demand driven by the global burden of heart disease. Market trends indicate a continuous need for advanced diagnostic tools that offer improved accuracy and patient outcomes in evaluating conditions like myocardial perfusion and coronary artery disease. Acusphere's Imagify positions the company within this competitive landscape, where it contends with established diagnostic imaging modalities and other contrast agents. While specific competitors are not detailed, the market includes major pharmaceutical and medical device companies offering a range of diagnostic solutions. Acusphere's niche strategy with Imagify aims to carve out a specific segment by providing a specialized injectable suspension, differentiating itself through the unique properties and application of perflubutane polymer microspheres in cardiac assessment.
Who Are ACUS's Key Customers?
- Cardiologists and cardiac imaging specialists.
- Hospitals and outpatient diagnostic centers.
- Medical professionals involved in the diagnosis of coronary artery disease.
- Healthcare systems requiring advanced cardiovascular diagnostic tools.
Research confidence
Thin evidence — scoring coverage unknown. Treat this as a starting point, not a conclusion.
- ● Scoring coverage unknown
- ● No usable price
- ● No filing on record
- ● No analyst coverage
Company Profile
Acusphere, Inc. operates in the Drug Manufacturers - Specialty & Generic industry within the Healthcare sector. It is headquartered in Watertown, US. The company is led by CEO William I. Ramage D.Phil. ACUS has traded publicly since 2003.
Financial Health
Acusphere, Inc.'s Piotroski F-Score is 3/9, a 9-point checklist of profitability, leverage and efficiency — flagging fundamental weakness worth scrutiny. Its Altman Z-Score of -30.04 places it in the distress zone, a signal of elevated financial risk.
Earnings Track Record
Acusphere, Inc. has missed Wall Street's EPS estimate in 6 of its last 8 reported quarters — a recurring pattern of falling short of estimates. Reported results have landed about 36.5% below estimates on average.
Insider Activity
12 transactions · 2 purchases, 0 sales, 10 other transactions · 2 identified insiders · most recent available transactions. Purchases and sales use the reported transaction category. Other transactions include awards, exercises, gifts, withholding and unclassified activity; an acquisition or disposition alone is not a purchase or sale. These records do not establish intent.
ACUS Financials
Fundamental Snapshot
Based on FMP financials and quantitative analysis
ACUS Latest News
No recent news available for ACUS.
ACUS Analyst Consensus
Consensus Rating
Aggregated Buy/Hold/Sell recommendations collected by Financial Modeling Prep for ACUS.
Price Targets
Wall Street price target analysis for ACUS.
ACUS MoonshotScore
MoonshotScore is Stock Expert AI's proprietary 0-100 research rating, not a buy or sell recommendation. No MoonshotScore is published for ACUS; grades run from A+ (80-100) to F (below 30).
Leadership: William I. Ramage D.Phil
Chief Executive Officer
William I. Ramage holds a D.Phil, indicating a strong academic and scientific background, likely in a field pertinent to pharmaceutical development, chemistry, or medicine. His leadership at Acusphere, Inc. positions him at the forefront of a specialty pharmaceutical company focused on cardiovascular drugs. With Acusphere's origins dating back to 1993, Dr. Ramage's tenure reflects a commitment to the company's long-term vision in developing specialized diagnostic agents. His expertise would be crucial in navigating the complex scientific, clinical, and regulatory landscapes inherent in the drug manufacturing industry.
Track Record: Under William I. Ramage's leadership, Acusphere, Inc. has continued its operations as a specialty pharmaceutical company, focusing on the commercialization of Imagify. His role involves overseeing the strategic direction, operational management, and any ongoing efforts related to the company's sole product, Imagify (perflubutane polymer microspheres). His leadership is essential in maintaining the company's presence in the cardiovascular diagnostics market and managing its operational challenges.
ACUS OTC Market Information
Acusphere, Inc. trades on the OTC market under the "OTC Other" tier. This tier is the lowest and least regulated segment of the OTC market, typically reserved for companies that do not meet the disclosure requirements for OTCQX or OTCQB, or that have chosen not to provide information to OTC Markets Group. Unlike companies listed on major exchanges like NYSE or NASDAQ, which adhere to strict listing standards regarding financial health, corporate governance, and disclosure, "OTC Other" companies face minimal reporting obligations. This often translates to significantly less publicly available information, making it challenging for investors to conduct thorough due diligence and assess the company's true financial and operational status.
- OTC Tier: OTC Other
- Limited or unknown public disclosure, making it difficult to assess financial health and operations.
- Extremely low liquidity and wide bid-ask spreads, leading to challenges in trading shares.
- Increased susceptibility to fraud and manipulation due to minimal regulatory oversight.
- Difficulty in obtaining reliable valuation metrics or analyst coverage.
- Higher volatility and potential for significant capital loss due to lack of market depth.
- Verify the company's current operational status and any ongoing business activities.
- Attempt to locate any available financial statements or regulatory filings, however limited.
- Research any news or press releases issued by the company, even if not formally filed.
- Investigate the background and current involvement of management and board members.
- Assess the commercial viability and market acceptance of Imagify, if any recent data exists.
- Understand the company's capital structure and any outstanding debt or equity raises.
- Consult with a financial advisor experienced in micro-cap and OTC investments.
- Founded in 1993, indicating a long-standing corporate entity, albeit with evolving status.
- Has a specific, named product, Imagify (perflubutane polymer microspheres), with a defined medical application.
- Operates in a legitimate industry (Drug Manufacturers - Specialty & Generic) with a physical HQ in Watertown, US.
- Identifiable CEO, William I. Ramage D.Phil, suggesting an active management structure.
Common Questions About ACUS (Healthcare)
What does Acusphere, Inc. do?
Acusphere, Inc. is a specialty pharmaceutical company focused on the development and commercialization of cardiovascular drugs. Its primary offering is Imagify (perflubutane polymer microspheres), an injectable suspension designed for diagnostic purposes.
Disclaimer: This content is for informational purposes only and does not constitute investment advice. Always do your own research and consult a financial advisor.
Official Resources
MoonshotScore is not published for this security.
Data provided for informational purposes only.
- Information is highly constrained by the limited source data provided, particularly regarding financial performance beyond basic metrics, operational details, and future pipeline.
- The market capitalization of $0.00 billion and deeply negative profit margin indicate significant financial challenges or a non-active public trading status, which limits the scope of traditional financial analysis.
- The 'OTC Other' classification and 'Unknown' disclosure status for the company significantly restrict the ability to assess its current operational health and future prospects comprehensively.
- Growth opportunities and CEO track record are inferred based on the company's stated business and general industry practices, without specific supporting data from the source.