ALPN: AI 评分 57/100 — AI 分析 (4月 2026)

Alpine Immune Sciences, Inc. is a clinical-stage biopharmaceutical company focused on developing protein-based immunotherapies. Their pipeline targets cancer, autoimmune/inflammatory disorders, and other diseases through innovative approaches to modulating the immune system.

Key Facts: AI Score: 57/100 Sector: Healthcare

公司概况

概要：

Alpine Immune Sciences, Inc. is a clinical-stage biopharmaceutical company specializing in protein-based immunotherapies for cancer and autoimmune diseases, leveraging its unique platform to develop novel treatments like ALPN-101, ALPN-202, and ALPN-303, positioning it within the competitive biotechnology landscape.

ALPN是做什么的？

Alpine Immune Sciences, Inc., founded in 2007 and headquartered in Seattle, Washington, is a clinical-stage biopharmaceutical company dedicated to discovering and developing innovative protein-based immunotherapies. The company's primary focus is on addressing significant unmet needs in cancer, autoimmune/inflammatory disorders, and other diseases. Alpine's scientific approach centers around modulating the immune system to achieve therapeutic benefits. Their product pipeline includes ALPN-101, an inducible T cell costimulator (ICOS)/cluster of differentiation 28 (CD28) antagonist designed for the treatment of autoimmune and inflammatory diseases. ALPN-202 is a conditional CD28 costimulator and dual checkpoint inhibitor being developed for cancer therapy. ALPN-303, a dual B cell cytokine antagonist, targets B cell-mediated inflammatory and autoimmune diseases. These programs represent Alpine's commitment to developing differentiated therapies with the potential to improve patient outcomes. Alpine has established strategic collaborations to advance its pipeline, including a partnership with AbbVie Ireland Unlimited Company for the development of ALPN-101 and a collaboration with Adaptimmune Therapeutics plc to develop next-generation SPEAR T cell products. The company's research and development efforts are geared towards creating novel immunotherapies that can offer improved efficacy and safety profiles compared to existing treatments.

ALPN的投资论点是什么？

Alpine Immune Sciences presents a notable market position within the biotechnology sector. The company's innovative pipeline, particularly ALPN-101, ALPN-202, and ALPN-303, targets significant unmet needs in autoimmune diseases and cancer. The collaboration with AbbVie for ALPN-101 validates the potential of Alpine's platform and provides financial resources for further development. Key value drivers include successful clinical trial outcomes for its lead programs, potential regulatory approvals, and expansion of its pipeline through internal research and strategic partnerships. A potential risk lies in the inherent uncertainty of clinical development and regulatory approval processes. The company's negative profit margin of -54.7% indicates that it is not currently profitable and relies on external funding or partnership revenue. Continued progress in clinical trials and strategic collaborations are essential for realizing the company's long-term value.

ALPN在哪个行业运营？

Alpine Immune Sciences operates within the competitive biotechnology industry, which is characterized by rapid innovation, high R&D costs, and stringent regulatory requirements. The market for immunotherapies is experiencing significant growth, driven by advances in understanding the immune system and the increasing prevalence of cancer and autoimmune diseases. Key trends include the development of personalized therapies, the use of combination therapies, and the exploration of new immune targets. Alpine competes with other biotechnology companies developing immunotherapies, as well as established pharmaceutical companies with existing products in these therapeutic areas. The company's success depends on its ability to develop differentiated therapies with improved efficacy and safety profiles.

Biotechnology

Healthcare

ALPN有哪些增长机遇？

Expansion of ALPN-101 into new autoimmune indications: ALPN-101, currently in development for autoimmune and inflammatory diseases, has the potential to be expanded into additional indications such as lupus, rheumatoid arthritis, and inflammatory bowel disease. The market for autoimmune disease therapies is estimated to reach $150 billion by 2028, offering a substantial growth opportunity for Alpine. Successful clinical trials and regulatory approvals in these new indications could significantly increase the value of ALPN-101.
Advancement of ALPN-202 in cancer immunotherapy: ALPN-202, a conditional CD28 costimulator and dual checkpoint inhibitor, represents a novel approach to cancer immunotherapy. The market for cancer immunotherapies is projected to reach $75 billion by 2027. Alpine can explore ALPN-202 in combination with other cancer therapies, such as checkpoint inhibitors and chemotherapy, to enhance its efficacy and broaden its applicability across different cancer types.
Development of ALPN-303 for B cell-mediated diseases: ALPN-303, a dual B cell cytokine antagonist, targets B cell-mediated inflammatory and autoimmune diseases. The market for B cell therapies is growing rapidly, driven by the increasing prevalence of autoimmune diseases and the development of more targeted therapies. Alpine can leverage its expertise in protein engineering to develop ALPN-303 as a differentiated therapy with improved efficacy and safety profiles.
Strategic partnerships and collaborations: Alpine can pursue additional strategic partnerships and collaborations with pharmaceutical companies and academic institutions to accelerate the development and commercialization of its pipeline. These partnerships can provide access to additional funding, expertise, and resources, as well as expand Alpine's reach into new markets and therapeutic areas. The collaboration with AbbVie for ALPN-101 serves as a successful example of this strategy.
Expansion into new therapeutic areas: Alpine can leverage its protein engineering platform to expand into new therapeutic areas beyond cancer and autoimmune diseases. This could include developing immunotherapies for infectious diseases, metabolic disorders, and other diseases with significant unmet needs. By diversifying its pipeline, Alpine can reduce its reliance on any single therapeutic area and create new growth opportunities.

Market Cap of $4.46B reflects investor confidence in Alpine's pipeline and technology.
P/E ratio of -100.94 indicates the company is currently not profitable, typical for clinical-stage biopharmaceutical companies.
Gross Margin of -37.4% reflects high R&D expenses associated with drug development.
Beta of 0.97 suggests the stock's volatility is similar to the overall market.
Collaboration agreement with AbbVie for ALPN-101 provides financial support and validation of the program's potential.

ALPN提供哪些产品和服务？

Develop protein-based immunotherapies.
Target cancer, autoimmune/inflammatory disorders, and other diseases.
Create inducible T cell costimulator (ICOS)/cluster of differentiation 28 (CD28) antagonists.
Develop conditional CD28 costimulators and dual checkpoint inhibitors.
Engineer dual B cell cytokine antagonists.
Collaborate with other companies to develop next-generation SPEAR T cell products.

ALPN如何赚钱？

Develop novel immunotherapies through internal research and development.
Out-license or co-develop its drug candidates with pharmaceutical partners.
Generate revenue through upfront payments, milestone payments, and royalties from partnered programs.

Pharmaceutical companies seeking to expand their immunotherapy portfolios.
Patients suffering from cancer and autoimmune/inflammatory disorders.
Healthcare providers who prescribe and administer immunotherapies.

Proprietary protein engineering platform for developing novel immunotherapies.
Strong intellectual property protection for its drug candidates.
Strategic collaborations with leading pharmaceutical companies.
Experienced management team with expertise in drug development and commercialization.

什么因素可能推动ALPN股价上涨？

Upcoming: Clinical trial data releases for ALPN-101 in autoimmune diseases.
Upcoming: Clinical trial data releases for ALPN-202 in cancer immunotherapy.
Ongoing: Enrollment and progression of patients in ongoing clinical trials.
Ongoing: Potential for new strategic partnerships and collaborations.

ALPN的主要风险是什么？

Potential: Clinical trial failures or regulatory setbacks.
Potential: Competition from other biotechnology and pharmaceutical companies.
Potential: Intellectual property challenges.
Ongoing: High R&D expenses and reliance on external funding.

ALPN的核心优势是什么？

Innovative protein engineering platform.
Promising pipeline of immunotherapies.
Strategic collaborations with major pharmaceutical companies.
Experienced management team.

ALPN的劣势是什么？

Clinical-stage company with no currently approved products.
High R&D expenses and negative profitability.
Reliance on external funding and partnerships.
Pipeline concentration on a few key programs.

ALPN有哪些机遇？

Expansion into new therapeutic areas and indications.
Advancement of pipeline programs through clinical development.
Further strategic partnerships and collaborations.
Potential for regulatory approvals and commercialization of its products.

ALPN面临哪些威胁？

Competition from other biotechnology and pharmaceutical companies.
Clinical trial failures and regulatory setbacks.
Intellectual property challenges.
Changes in the regulatory landscape.

ALPN的竞争对手是谁？

Astellas Pharma Inc — Focuses on prescription pharmaceuticals and consumer healthcare. — (ASPHF)
CymaBay Therapeutics Inc — Develops and commercializes therapies for liver and other chronic diseases. — (CBAY)
ChemoCentryx Inc — Focuses on autoimmune diseases, inflammatory disorders and cancer. — (CCXI)
Global Blood Therapeutics Inc — Develops and commercializes therapies for sickle cell disease. — (GBT)
Isee Pharma Inc — Develops innovative ophthalmic therapeutics. — (ISEE)

Key Metrics

MoonshotScore: 57/100

Company Profile

CEO: Mitchell H. Gold
Headquarters: Seattle, US
Employees: 142
Founded: 2015

AI Insight

AI analysis pending for ALPN

常见问题

What does Alpine Immune Sciences, Inc. do?

Alpine Immune Sciences, Inc. is a clinical-stage biopharmaceutical company that specializes in developing protein-based immunotherapies. Their focus is on creating innovative treatments for cancer, autoimmune disorders, and inflammatory diseases by modulating the immune system. The company's pipeline includes ALPN-101, ALPN-202, and ALPN-303, each designed to target specific pathways involved in immune regulation. Alpine aims to develop therapies that offer improved efficacy and safety profiles compared to existing treatments, addressing unmet medical needs in these therapeutic areas. They operate by researching, developing, and partnering to bring novel immunotherapies to market.

What do analysts say about ALPN stock?

Analyst consensus on Alpine Immune Sciences is pending further analysis. However, key valuation metrics to consider include the company's market capitalization of $4.46B and its negative P/E ratio of -100.94, reflecting its current lack of profitability. Growth considerations revolve around the successful advancement of its pipeline programs through clinical trials and potential regulatory approvals. The collaboration with AbbVie for ALPN-101 is a positive sign, but the company's high R&D expenses and reliance on external funding remain factors to watch.

What are the main risks for ALPN?

The main risks for Alpine Immune Sciences include the inherent uncertainties of clinical development, such as the potential for clinical trial failures or regulatory setbacks. Competition from other biotechnology and pharmaceutical companies developing similar therapies also poses a risk. Intellectual property challenges and the need to secure and maintain patent protection are critical considerations. Additionally, the company's high R&D expenses and reliance on external funding make it vulnerable to changes in the financial markets and investor sentiment. These factors could impact Alpine's ability to advance its pipeline and achieve its long-term goals.