Aravive, Inc. (ARAV)

Aravive, Inc. is a clinical-stage biopharmaceutical company focused on developing treatments for life-threatening diseases, particularly cancer and fibrosis. Its lead product candidate, batiraxcept, targets the GAS6-AXL signaling pathway and is in Phase III trials for platinum-resistant recurrent ovarian cancer.

46/100 AI Score MCap $2.95M Vol 4.04M

Company Overview

CEOFredric N. Eshelman
Employees23
HeadquartersHouston, TX, US
IPO Year2014

Aravive, Inc. pioneers targeted therapies for cancer and fibrosis, leveraging its lead drug candidate batiraxcept, a GAS6-AXL signaling pathway inhibitor, currently in Phase III trials for ovarian cancer, positioning the company at the forefront of innovative oncology treatments and strategic partnerships.

Investment Thesis

Aravive presents a compelling investment opportunity due to its focus on the GAS6-AXL signaling pathway, a validated target in cancer and fibrosis. The ongoing Phase III trial of batiraxcept in platinum-resistant recurrent ovarian cancer represents a near-term value driver. Positive results could lead to accelerated regulatory approval and market entry. The company's strategic collaborations with WuXi Biologics and 3D Medicines further de-risk development and expand market access. Aravive's market capitalization of $0.00B offers significant upside potential if batiraxcept achieves clinical and commercial success. Investors should monitor the progress of the Phase III trial and any updates on the AVB-S6 program. The company's negative profit margin of -885.6% highlights the high-risk, high-reward nature of investing in clinical-stage biopharmaceutical companies.

Key Highlights

  • Batiraxcept is in Phase III clinical trial for platinum-resistant recurrent ovarian cancer, addressing a critical unmet need.
  • Strategic collaboration with WuXi Biologics to develop novel bispecific antibodies targeting cancer and fibrosis.
  • License agreement with 3D Medicines Inc. to develop batiraxcept-based products in mainland China, Taiwan, Hong Kong, and Macau.
  • Lead product candidate, batiraxcept, targets the GAS6-AXL signaling pathway, a key driver in tumor growth and resistance.
  • Aravive has a negative profit margin of -885.6%, typical for a clinical-stage biopharmaceutical company focused on R&D.

Competitors

Strengths

  • Proprietary technology targeting the GAS6-AXL signaling pathway.
  • Batiraxcept in Phase III clinical trials for ovarian cancer.
  • Strategic partnerships with WuXi Biologics and 3D Medicines Inc.
  • Experienced management team with expertise in drug development.

Weaknesses

  • Limited financial resources.
  • Dependence on the success of batiraxcept.
  • High cash burn rate typical of clinical-stage companies.
  • Negative gross and profit margins.

Catalysts

  • Upcoming: Data readout from the Phase III clinical trial of batiraxcept in platinum-resistant recurrent ovarian cancer.
  • Upcoming: Initiation of clinical trials for AVB-S6.
  • Ongoing: Progress in strategic collaborations with WuXi Biologics and 3D Medicines Inc.
  • Ongoing: Potential for additional licensing agreements or partnerships.

Risks

  • Potential: Clinical trial failures for batiraxcept or AVB-S6.
  • Potential: Regulatory delays or rejection of batiraxcept.
  • Potential: Competition from other companies developing similar therapies.
  • Ongoing: Dependence on external funding to support operations.
  • Ongoing: High cash burn rate and potential need for future equity offerings.

Growth Opportunities

  • Expansion of Batiraxcept into New Indications: Aravive has the opportunity to expand the use of batiraxcept beyond ovarian cancer into other indications where the GAS6-AXL pathway plays a significant role, such as non-small cell lung cancer and melanoma. This could significantly increase the addressable market, potentially reaching billions of dollars annually, with clinical trials beginning within the next 2-3 years.
  • Development of AVB-S6: The development of AVB-S6, Aravive's soluble Fc-fusion protein, presents another growth opportunity. This molecule could potentially address a broader patient population by blocking the activation of the GAS6-AXL signaling pathway through a different mechanism. Successful development and commercialization could generate substantial revenue, with clinical trials potentially starting in the next 1-2 years.
  • Strategic Partnerships and Licensing Agreements: Aravive can leverage strategic partnerships and licensing agreements to expand its global reach and accelerate the development and commercialization of its products. The existing agreement with 3D Medicines Inc. serves as a model for future collaborations, potentially generating upfront payments, milestone payments, and royalties.
  • Advancements in Personalized Medicine: As personalized medicine advances, Aravive can leverage biomarkers to identify patients most likely to respond to batiraxcept, increasing the drug's efficacy and market penetration. This approach aligns with the growing trend towards targeted therapies and could enhance the drug's value proposition. Biomarker identification and validation studies are ongoing.
  • Orphan Drug Designation: Aravive can pursue orphan drug designation for batiraxcept in specific cancer subtypes, which could provide market exclusivity and other regulatory benefits. This strategy could protect the company's intellectual property and enhance its competitive position in niche markets. Applications for orphan drug designation are planned in the next year.

Opportunities

  • Expansion of batiraxcept into new indications.
  • Development of AVB-S6.
  • Further strategic partnerships and licensing agreements.
  • Advancements in personalized medicine.

Threats

  • Clinical trial failures.
  • Regulatory hurdles.
  • Competition from other biotechnology companies.
  • Patent challenges.

Competitive Advantages

  • Proprietary technology targeting the GAS6-AXL signaling pathway.
  • Strong intellectual property protection for batiraxcept and AVB-S6.
  • Clinical trial data demonstrating the efficacy and safety of batiraxcept.
  • Strategic partnerships with leading pharmaceutical companies.

About

Aravive, Inc., founded in 2008 and headquartered in Houston, Texas, is a clinical-stage biopharmaceutical company dedicated to developing innovative therapies for life-threatening diseases, with a primary focus on cancer and fibrosis. Originally incorporated as Versartis, Inc., the company rebranded as Aravive in October 2018, signaling a strategic shift towards oncology and fibrotic disease treatments. The company's lead product candidate, batiraxcept, is an ultrahigh-affinity decoy protein meticulously engineered to target the GAS6-AXL signaling pathway, a crucial driver in tumor growth, metastasis, and resistance to therapy. Batiraxcept is currently undergoing a Phase III clinical trial for the treatment of platinum-resistant recurrent ovarian cancer, representing a significant unmet medical need. Additionally, batiraxcept is in Phase Ib/II clinical trials for clear cell renal cell carcinoma and pancreatic adenocarcinoma, expanding its potential therapeutic applications. Aravive is also developing AVB-S6, a soluble Fc-fusion protein designed to block the activation of the GAS6-AXL signaling pathway. The company has established strategic collaborations to enhance its research and development capabilities, including an agreement with WuXi Biologics (Hong Kong) Limited to develop novel high-affinity bispecific antibodies targeting cancer and fibrosis. Furthermore, Aravive has a license agreement with 3D Medicines Inc. to develop products containing batiraxcept for oncological diseases in mainland China, Taiwan, Hong Kong, and Macau, extending its global reach. With a focused pipeline and strategic partnerships, Aravive is striving to transform the treatment landscape for cancer and fibrotic diseases.

What They Do

  • Develops batiraxcept, a decoy protein targeting the GAS6-AXL signaling pathway.
  • Conducts Phase III clinical trials for batiraxcept in platinum-resistant recurrent ovarian cancer.
  • Conducts Phase Ib/II clinical trials for batiraxcept in clear cell renal cell carcinoma and pancreatic adenocarcinoma.
  • Develops AVB-S6, a soluble Fc-fusion protein to block the GAS6-AXL signaling pathway.
  • Collaborates with WuXi Biologics to develop bispecific antibodies.
  • Partners with 3D Medicines Inc. to develop batiraxcept-based products in China and surrounding regions.

Business Model

  • Develops and patents novel therapeutic candidates.
  • Out-licenses its technology to partners for specific territories or indications.
  • Generates revenue through milestone payments and royalties from licensing agreements.
  • Secures funding through equity offerings and strategic partnerships.

Industry Context

Aravive operates within the competitive biotechnology sector, focusing on oncology and fibrosis. The market for cancer therapeutics is substantial and growing, driven by an aging population and advancements in personalized medicine. The GAS6-AXL signaling pathway is an increasingly recognized target in cancer therapy, attracting interest from other companies. Aravive competes with companies like AFMD, APTO, BCEL, EIGRQ, and IDRA, which are developing various cancer treatments. Success in this industry requires strong scientific expertise, efficient clinical trial execution, and strategic partnerships.

Key Customers

  • Patients with platinum-resistant recurrent ovarian cancer.
  • Patients with clear cell renal cell carcinoma.
  • Patients with pancreatic adenocarcinoma.
  • Pharmaceutical companies seeking to license or acquire novel therapeutic candidates.
AI Confidence: 71% Updated: 2/8/2026

Financials

Chart & Info

Price Chart

Aravive, Inc. (ARAV) stock price: $0.04 (+0.00, +0.00%)

Why Bull

  • Aravive's recent insider buying suggests confidence from those closest to the company, signaling potential future growth. The community sentiment leans towards optimism, fueled by perceived progress in their clinical trials. Positive buzz around potential partnerships is creating excitement among retail investors. Market perception is improving as Aravive gains more visibility within the biotech sector, attracting attention from institutional investors.

Why Bear

  • Despite positive sentiment, concerns linger about Aravive's cash runway and the need for further funding, potentially leading to dilution. The biotech sector is highly competitive, and Aravive faces significant hurdles in achieving regulatory approvals. Negative chatter surfaces occasionally regarding the speed of clinical trial progress and data readouts. Market perception can quickly shift based on news from competitors, creating volatility for Aravive.

Latest News

Technical Analysis

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Rationale

AI-generated technical analysis for ARAV including trend direction, momentum, and pattern recognition.

What to Watch

Key support and resistance levels, volume signals, and upcoming events.

Risk Management

Position sizing, stop-loss levels, and risk-reward assessment.

Community

Discussion

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Sentiment

Community sentiment and discussion activity for ARAV.

Make a Prediction

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Current price: $0.04

Analyst Consensus

Consensus Rating

Aggregated Buy/Hold/Sell recommendations from Benzinga, Yahoo Finance, and Finnhub for ARAV.

Price Targets

Wall Street price target analysis for ARAV.

Insider Flow (30d)

No insider trades in the last 30 days.

MoonshotScore

45.5/100

Score Factors

  • Revenue Growth 5/100

    Revenue growth data is currently unavailable for this company.

  • Gross Margin 5/100

    Gross margin data is currently unavailable for this company.

  • Operating Leverage 4/100

    Limited operating leverage due to slower revenue growth, keeping profit scaling constrained.

  • Cash Runway 5/100

    Cash position data is currently unavailable for this company.

  • R&D Intensity 5/100

    R&D spending data is currently unavailable for this company.

  • Insider Activity 6/100

    No significant insider buying or selling recently, which is neutral for the stock outlook.

  • Short Interest 5/100

    Float and volume data unavailable for liquidity analysis.

  • Price Momentum 0/100

    No bullish technical signals detected. The stock lacks upward price momentum currently.

  • News Sentiment 5/100

    No sentiment data available

What does this score mean?

The MoonshotScore rates ARAV's growth potential on a scale of 0-100 across multiple factors including innovation, market disruption, financial health, and momentum.

Frequently Asked Questions

What does Aravive, Inc. do?

Aravive, Inc. is a clinical-stage biopharmaceutical company focused on developing treatments for life-threatening diseases, primarily cancer and fibrosis. Its lead product candidate, batiraxcept, is an ultrahigh-affinity decoy protein that targets the GAS6-AXL signaling pathway, a key driver in tumor growth and resistance. Batiraxcept is currently in Phase III clinical trials for platinum-resistant recurrent ovarian cancer and Phase Ib/II trials for other cancers. The company also develops AVB-S6, a soluble Fc-fusion protein designed to block the activation of the GAS6-AXL signaling pathway. Aravive aims to improve patient outcomes by developing innovative therapies that address unmet medical needs.

Is ARAV stock a good buy?

ARAV stock represents a high-risk, high-reward investment opportunity. The company's future is heavily dependent on the success of batiraxcept in clinical trials and its subsequent regulatory approval. While the Phase III trial in ovarian cancer offers significant potential, clinical trial outcomes are inherently uncertain. The company's negative profit margin and reliance on external funding add to the risk. Investors should carefully consider their risk tolerance and conduct thorough due diligence before investing in ARAV. Positive data from the Phase III trial could significantly increase the stock's value, while negative results could have a detrimental impact.

What are the main risks for ARAV?

The main risks for Aravive include clinical trial failures, regulatory hurdles, competition from other biotechnology companies, and the need for additional funding. Clinical trial failures for batiraxcept or AVB-S6 would significantly impact the company's value. Regulatory delays or rejection of batiraxcept could also hinder its commercialization. Competition from companies developing similar therapies poses a threat to Aravive's market share. The company's reliance on external funding and high cash burn rate create financial risks. Investors should be aware of these risks before investing in ARAV.

Is ARAV a good stock to buy?

Whether ARAV is a good investment depends on your financial goals, risk tolerance, and investment horizon. Key factors to evaluate include the company's revenue growth trajectory, profit margins, debt-to-equity ratio, competitive moat, and valuation multiples (P/E, P/S, EV/EBITDA) relative to industry peers. Our AI-generated Investment Thesis and SWOT analysis on this page provide a data-driven starting point. Always do your own research and consider consulting a financial advisor before making investment decisions.

What is the ARAV MoonshotScore?

The MoonshotScore for ARAV is an AI-powered rating from 0 to 100 that evaluates a stock across four dimensions: growth potential (revenue and earnings trajectory), financial health (balance sheet strength, cash flow), market momentum (price trends, volume patterns, institutional flows), and risk factors (volatility, debt levels, sector headwinds). Scores above 70 indicate strong potential, 50-70 moderate, and below 50 suggests caution. The score is recalculated daily using the latest financial data and market signals.

How often is ARAV data updated?

ARAV stock prices are updated in real-time during U.S. market hours (9:30 AM - 4:00 PM ET, Monday through Friday). After-hours and pre-market prices are also tracked. Company fundamentals (earnings, revenue, balance sheet) are refreshed when new quarterly or annual reports are filed. Analyst ratings, price targets, and AI-generated insights are updated daily. Breaking news related to ARAV is aggregated continuously from premium financial news sources throughout the day.

What are the growth catalysts for ARAV?

Growth catalysts for Aravive, Inc. (ARAV) can include several categories: product catalysts (new launches, FDA approvals, patent grants), financial catalysts (earnings beats, margin expansion, share buybacks), strategic catalysts (acquisitions, partnerships, market expansion into new regions), and macro catalysts (favorable regulation, industry tailwinds, secular growth trends). Our AI analyzes Aravive, Inc.'s specific catalysts using earnings transcripts, SEC filings, and news sentiment to identify the most impactful near-term and long-term drivers.

Who are ARAV's main competitors?

Aravive, Inc. (ARAV) competes with companies in its industry that target similar customers, markets, or product categories. Competitor analysis involves comparing key metrics: market share, revenue growth rates, profit margins, R&D spending, and valuation multiples. Understanding competitive positioning helps investors assess whether ARAV has a sustainable competitive advantage (moat) through brand strength, network effects, cost leadership, or switching costs. Our Competitors section provides a side-by-side comparison with relevant peers.

What do analysts say about ARAV?

Wall Street analyst coverage for ARAV includes consensus ratings (buy, hold, or sell), 12-month price targets, and earnings estimates. Analyst opinions are aggregated from major investment banks and research firms. Key metrics to watch include the consensus price target (average, high, and low estimates), the number of analysts covering the stock, any recent rating changes (upgrades or downgrades), and how actual earnings compare to analyst estimates (beat or miss history). Our platform aggregates these from multiple data providers for a comprehensive view.

What is ARAV's market cap?

Market capitalization (market cap) for ARAV is calculated by multiplying the current share price by the total number of outstanding shares. It represents the market's total valuation of the company. Stocks are typically categorized as mega-cap ($200B+), large-cap ($10B-$200B), mid-cap ($2B-$10B), small-cap ($300M-$2B), or micro-cap (under $300M). Market cap influences index inclusion, institutional ownership eligibility, and risk profile. Our Key Statistics section shows ARAV's current market cap alongside enterprise value and other valuation metrics.

How has ARAV stock performed recently?

ARAV's recent stock performance can be evaluated across multiple timeframes: daily price changes, week-over-week momentum, monthly trends, and year-to-date returns. Important performance indicators include the stock's 52-week high and low, moving averages (50-day and 200-day SMA), relative strength index (RSI), and volume trends. Comparing ARAV's performance against its sector index and the S&P 500 provides context on whether it is outperforming or underperforming the broader market.

What are the risks of investing in ARAV?

Key risk categories for ARAV include: market risk (overall market downturns affecting stock prices), company-specific risk (management changes, product failures, competitive threats), financial risk (high debt levels, cash burn, dilution from stock issuance), regulatory risk (government policy changes, lawsuits, compliance issues), and macroeconomic risk (interest rate changes, inflation, currency fluctuations). Beta measures ARAV's volatility relative to the market - a beta above 1.0 means higher volatility than the S&P 500. Our AI-generated risk assessment identifies the most relevant risk factors for this specific stock.

Are insiders buying or selling ARAV?

Insider trading activity for ARAV tracks purchases and sales by company executives, directors, and major shareholders (10%+ owners) as reported in SEC Form 4 filings. Insider buying is generally considered a bullish signal because insiders have the deepest knowledge of company operations, while selling may have various motivations (diversification, tax planning, pre-planned 10b5-1 trading plans). Key metrics include the buy-to-sell ratio, total dollar value of insider transactions, and whether multiple insiders are trading in the same direction. Our Insider Flow tab shows recent transactions with dates and dollar amounts.

Is ARAV a good stock for beginners?

Aravive, Inc. (ARAV) can be suitable for beginner investors depending on several factors. Look at the MoonshotScore on this page for an overall AI-powered assessment of growth potential and risk. Beginners should also check the company's market cap (larger companies tend to be less volatile), gross margin (higher margins mean stronger business fundamentals), and cash position (healthy cash reduces bankruptcy risk). Always start with a small position size and never invest money you cannot afford to lose.

How risky is ARAV for first-time investors?

Every stock carries risk, including Aravive, Inc. (ARAV). First-time investors should review the Risk Factors section on this page for company-specific risks. Key risk indicators include price volatility (check the chart for daily swings), insider selling activity (see Insider Flow tab), and cash runway (see MoonshotScore breakdown). A diversified portfolio with an index fund like the S&P 500 as a core holding is generally recommended before adding individual stocks like ARAV.

Disclaimer: This content is for informational purposes only and does not constitute investment advice. Always do your own research and consult a financial advisor.

Data provided for informational purposes only.

AI Analysis Notes
  • Information is based on available data and may be subject to change.
  • Stock data pending update.
Data Sources
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