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Alnylam Pharmaceuticals, Inc. (ALNY) Stock: Price, Forecast & Analyst Target

Alnylam Pharmaceuticals, Inc. (ALNY) — MoonshotScore 89/100 (Exceptional band), calculated Oct 6, 2026. Price $219.89 (+0.08%), as of the Oct 5, 2026 trading session; market cap $29.4B.

Educational signal · not a buy or sell recommendation · How to read this

$219.89 +$0.17 (+0.08%) Market Cap $29.4B

Alnylam Pharmaceuticals, Inc. · ALNY · NASDAQ · Healthcare · Biotechnology

Research dated 2026-09-12: Alnylam is a commercial biopharmaceutical company built around RNA interference: approved rare-disease medicines support an expanding development engine, while alliances extend the platform into additional organs and diseases. Its appeal now depends on whether commercial growth can keep supporting profit and cash generation as research and commercialization costs remain substantial.

Price as of Oct 5, 2026

Key Statistics

89 of 100

MoonshotScore v2 · Alnylam Pharmaceuticals (ALNY)

Exceptional
Business Quality Elite (96)
Financial Safety Okay (59)
Valuation Full (41)
Growth Durability Compounding (100)
Momentum Slipping (28)
Why this rating? Method, drivers & history

Bands for the MoonshotScore: Exceptional 80-100 · Strong 65-79 · Fair 45-64 · Weak below 45.

  • Business Quality — Is this a genuinely good business?
  • Financial Safety — Could this blow up on me?
  • Valuation — Am I paying a fair price?
  • Growth Durability — Is the growth real and likely to last?
  • Momentum — Is the market already moving on this?
The ten-second read ·

Elite quality and elite growth, though the balance sheet is only decent, and the price trend has turned against it. Business Quality: Elite; Financial Safety: Okay; Valuation: Full; Growth Durability: Compounding; Momentum: Slipping.

  • quarterly revenue $1.29B (Q2 FY2026, quarter ended Jun 2026)
  • EPS beat 5 of 8
  • Altman Z 4.79 · Piotroski F 6

Holding back: weak price trend

Helping: business quality, durable growth

What has the MoonshotScore done over time?

MoonshotScore snapshots recorded for ALNY (30 recorded, newest six shown)
RecordedScoreBand
90Exceptional
91Exceptional
91Exceptional
91Exceptional
91Exceptional
89Exceptional

The score was 89 in the stored Oct 5, 2026 snapshot and remains 89 in the current publication computed Oct 6, 2026 (0); the largest pillar moves were Valuation +1 and Momentum +1; the pillar moves offset under the sector-relative weighting, so the headline score is unchanged. This current publication is not yet represented in the immutable snapshot archive.

Calculation uses the most recent completed US trading session. Live price changes do not update the score immediately.

Computed · Educational signal · not a buy or sell recommendation · How the MoonshotScore is computed →

Price & valuation

Dates shown where recorded
MeasureValueAs of
Latest provided price$219.89
Change on the day+0.08%
52-week range$197.81–$495.55
Market capitalisation$29.4B
Price / earnings (trailing)36.05
Shares traded on the day1.28M
Beta (volatility vs the S&P 500)0.3

Price & events

Weekly closing price with reported quarters marked Weekly closing price from Sep 5, 2025 to Oct 5, 2026: low $206, high $482, latest $220. $482 $206 high $482 Sep 5, 2025 Oct 5, 2026 · $220 $452Sep 5, 2025$454Sep 19, 2025$456Oct 3, 2025$482Oct 17, 2025$456Oct 31, 2025$449Nov 14, 2025$451Nov 28, 2025$398Dec 12, 2025$401Dec 26, 2025$398Jan 9, 2026$358Jan 23, 2026$328Feb 6, 2026$336Feb 20, 2026$321Mar 6, 2026$312Mar 20, 2026$319Apr 2, 2026$310Apr 17, 2026$296May 1, 2026$287May 15, 2026$302May 29, 2026$283Jun 12, 2026$291Jun 26, 2026$299Jul 10, 2026$272Jul 24, 2026$219Aug 7, 2026$236Aug 21, 2026$266Sep 4, 2026$240Sep 18, 2026$220Oct 2, 2026

Point at or tab to any week for its close.

Other perspectives

Council score for Alnylam Pharmaceuticals (ALNY): perspectives

Council is a separate blend of available disciplines; MoonshotScore above remains the five-pillar research rating.

5-Factor Breakdown

Growth Durability Strong
Momentum Weak
Business Quality Strong
Financial Safety Neutral
Valuation Neutral

Legends Council

4 lenses, 0 current

AI simulations built from the named investors' published principles. Not affiliated with, endorsed by, or the opinion of these individuals. How these lenses are built

Griffin-style lens (simulated) Ken Griffin Favorable read
Englander-style lens (simulated) Izzy Englander Unfavorable read
Klarman-style lens (simulated) Seth Klarman Unfavorable read
Moon AI lens (model) Favorable read

Read on: Oct 5, 2026 · older than the 27 hours refresh window; not a current reading

Munger's Mindset

Balance Sheet & Valuation · historical

Financial Health Moderate
Margin of Safety Overvalued
Profit Margin Moderate
Revenue Growth Strong
Debt/Equity Weak
ROE Strong
Gross Margin Strong

Read on: Sep 10, 2026 · older than the 27 hours refresh window; not a current reading

How to read these bars and different assessments

Council is a separate blend of available disciplines; MoonshotScore above remains the five-pillar research rating.

Bars show each model's ordered assessment on its own scale, not a probability or a comparable investment return. The adjacent words give the assessment; more filled segments indicate a stronger model reading.

On Sep 10, 2026, the Munger lens read the price at that time as overvalued against its own estimate of value.

Readings on this page are from Oct 6, 2026, except a card that shows its own read date.

Watch the ALNY film — every key number, told as a short cinematic story

~2 min · open the film

1 · What is it?

What is Alnylam Pharmaceuticals (ALNY), and what does it report?

Short answer · as of

Alnylam discovers, develops, and commercializes medicines that use RNA interference to silence disease-causing targets.

Research dated 2026-09-12.

Alnylam discovers, develops, and commercializes medicines that use RNA interference to silence disease-causing targets. Demand comes from prescribing and patient access for approved therapies such as GIVLAARI, ONPATTRO, and OXLUMO; pipeline progress and partnerships broaden the business beyond those brands.

This is not merely a research platform awaiting commercialization. Consolidated results reflect a commercial drug business alongside heavy internal development and alliance activity, while the named segment view highlights GIVLAARI and ONPATTRO without serving as a complete map of revenue.

Sources (as of 2026-09-12): Business description; Revenue by segment; Annual revenue and net result (USD millions); Quarterly income statement (USD thousands)

2 · Latest results

What do the latest results show for Alnylam Pharmaceuticals (ALNY)?

Short answer · as of

The most recent reported quarter, Q2 FY2026, carried revenue of $1.29B.

Research dated 2026-09-12.

Revenue and gross profit advanced from the preceding period, but operating profit, net income, and diluted earnings per share retreated as research and selling and administrative costs climbed. The latest release also landed below revenue and earnings expectations, making cost absorption—not merely top-line growth—the immediate operating test.

Management has attached a longer-duration catalyst to nucresiran in hATTR polyneuropathy, with any launch conditional on favorable late-stage results and regulatory approval. That is an ambition with explicit gates, not evidence that commercial contribution has begun.

Sources (as of 2026-09-12): Quarterly income statement (USD thousands); Operating cash flow by quarter (USD millions); Reported versus estimated, last 8 quarters; Management outlook — dated call excerpts

Where is operating spending going?

Revenue alongside research and development, selling, general and administrative expenses, and the FMP standardized operating result.

Where is operating spending going? — FMP standardized evidence
Period endRevenueR&DSG&AFMP standardized operating result
Jun 30, 2026Not availableNot availableNot availableNot available
Mar 31, 2026Not availableNot availableNot availableNot available
Dec 31, 2025Not availableNot availableNot availableNot available
Sep 30, 2025Not availableNot availableNot availableNot available

USD. The operating result is the FMP-standardized value supplied by FMP; it may differ from a filing’s GAAP loss from operations when the provider classifies separately presented items differently. It is not net income or cash flow.

Quarterly income statement — 4 quarters
Revenue, net income and earnings per share by quarter
PeriodRevenueNet incomeEPS
Q2 FY2026$1.29B$164M$1.19 (diluted)
Q1 FY2026$1.17B$206M$1.49 (diluted)
Q4 FY2025$1.10B$186M$1.37 (diluted)
Q3 FY2025$1.25B$251M$1.83 (diluted)
3 · Financial strengths and risks

What are the financial strengths and risks for Alnylam Pharmaceuticals (ALNY)?

Short answer

Cash and short-term investments were $0.00 at the Jun 30, 2026 balance-sheet date. This figure does not establish a cash runway.

Research dated 2026-09-12.

Cash and short-term investments exceed total debt by a wide margin, have risen across recent reporting points, and sit alongside positive operating cash flow in the latest periods. This gives Alnylam meaningful capacity to fund research and commercialization while maintaining net cash.

Risk now sits less in immediate financing pressure than in execution against a large cost base. Research and selling expenses remain substantial and increased in the latest period; if commercial growth weakens or a major program stalls, operating profit and cash generation can compress quickly. Valuation ratios also place considerable weight on continued earnings delivery, despite uneven results relative to expectations.

Sources (as of 2026-09-12): Cash, investments and debt; Cash and investment components; Cash and short-term investments over time (USD millions); Cash against market value; Operating cash flow by quarter (USD millions); Trailing twelve-month ratio set; Quarterly income statement (USD thousands); Reported versus estimated, last 8 quarters

4 · What to check next?

What should you watch next at Alnylam Pharmaceuticals (ALNY)?

Short answer · as of

Current published price targets run low $256.00 · high $455.00 · consensus $347.33 · median $334.00 against a quoted price of $219.89 (as of Oct 5, 2026).

Research dated 2026-09-12.

At the next release, compare revenue growth with published expectations, then trace how much reaches gross profit after research and commercialization spending. Operating cash flow, capital spending, and the cash balance will show whether accounting profitability is translating into additional funding capacity.

Beyond the financial statements, nucresiran’s late-stage result and regulatory path are the concrete gates behind management’s launch timetable. Longer-range analyst estimates assume sustained expansion but span a broad range, so any narrowing would signal greater confidence in commercial scaling.

Sources (as of 2026-09-12): Next earnings report; Analyst revenue and earnings estimates (average); Quarterly income statement (USD thousands); Operating cash flow by quarter (USD millions); Cash and short-term investments over time (USD millions); Management outlook — dated call excerpts

What the records here don't tell us

  • No forward revenue or earnings estimate is on file.
  • The next earnings date is not yet scheduled in the calendar we read.

Checked against the records this page reads, on the dates shown above.

5 · Peer comparison

How does Alnylam Pharmaceuticals compare with its peers?

Short answer

Alnylam Pharmaceuticals's score ranks 2nd of 6 in the bounded comparison shown, against 5 same-model peers. These are company scores, not expected investment returns. The set lists named competitors first, then companies in the same data-provider industry classification closest in market value; that classification is the provider's, not our judgment of business similarity.

Research dated 2026-09-12.

Alnylam belongs between commercial specialty biopharma and platform biotechnology. Unlike a development-only biotech, it has approved RNAi medicines, positive recent earnings, operating cash generation, and net cash; unlike a conventional drug portfolio, its identity and pipeline remain concentrated around a shared gene-silencing technology and amplified through external alliances.

The practical comparison is therefore broader than pipeline breadth or current sales. Relevant distinctions include the durability of branded demand, the productivity of continuing research spending, and the balance between internal programs and alliances.

Sources (as of 2026-09-12): Sector / industry (provider taxonomy); Business description; Annual revenue and net result (USD millions); Quarterly income statement (USD thousands); Operating cash flow by quarter (USD millions); Cash against market value

Peer set — price, market value and MoonshotScore
CompanyPriceMarket valueScore
Regeneron Pharmaceuticals, Inc. (REGN) Named competitor$726.94 Oct 5, 2026$74.9B94 5-pillar Oct 6, 2026
Alnylam Pharmaceuticals (ALNY) — this page$219.89$29.4B89
Zoetis Inc. (ZTS) Named competitor$71.41 Oct 5, 2026$29.9B87 5-pillar Oct 6, 2026
Cencora, Inc. (COR) Named competitor$314.93 Oct 5, 2026$61.3B82 5-pillar Oct 6, 2026
Cigna Corporation (CI) Named competitor$271.29 Oct 5, 2026$71.7B81 5-pillar Oct 6, 2026
Becton, Dickinson and Company (BDX) Named competitor$180.67 Oct 5, 2026$49.8B73 5-pillar Oct 6, 2026
Royalty Pharma plc (RPRX) Same industry, near in market value$56.66 Date unavailable$25.1B— Model unavailable
Incyte Corporation (INCY) Same industry, near in market value$113.81 Date unavailable$23.1B— Model unavailable
United Therapeutics Corporation (UTHR) Same industry, near in market value$536.40 Date unavailable$22.8B— Model unavailable
argenx SE (ARGX) Same industry, near in market value$919.21 Date unavailable$57.2B— Model unavailable
Exelixis, Inc. (EXEL) Same industry, near in market value$58.85 Date unavailable$14.8B— Model unavailable
Neurocrine Biosciences, Inc. (NBIX) Same industry, near in market value$144.21 Date unavailable$14.5B— Model unavailable
Ascendis Pharma A/S (ASND) Same industry, near in market value$228.03 Date unavailable$14.2B— Model unavailable

Only 5-pillar scores are ranked together. Other models are not directly comparable. Price and score dates are shown separately; market-value dates are unavailable.

Screen more Healthcare stocks

The records behind this page

Analyst targets & estimates

What analysts have on file

Price target, low to high
$256.00 – $455.00
Consensus target
$347.33
Median target
$334.00

Consensus record · Captured .

Measured against a quoted price of $219.89 (as of Oct 5, 2026).

Insider activity

Form 4 records via FMP · Of the newest 100 records, those within the last 180 days, newest dated Sep 19, 2026

Transactions
29
Identified insiders
11
Purchases
0
Sales
5
Other transactions
24

Purchases and sales use the reported transaction category. Other transactions include awards, exercises, gifts, withholding and unclassified activity; an acquisition or disposition alone is not a purchase or sale. These records do not establish intent.

Common Questions About ALNY (Healthcare)

Research dated 2026-09-12; the answers below are from that research, and the full attribution is under Sources. The last 2 questions are answered from this page's own dated data, not from the research.

How does Alnylam make money from RNA interference?

The operating model combines sales of approved therapies with partnered development and commercialization. The named segment view includes GIVLAARI and ONPATTRO, while consolidated revenue is materially broader than those disclosed lines.

Sources (as of 2026-09-12): Business description; Revenue by segment; Annual revenue and net result (USD millions)

Why did Alnylam’s profit fall while revenue rose in the latest period?

Research and selling and administrative costs increased enough to outweigh the rise in gross profit. Revenue still expanded, but less of that growth reached operating profit and net income.

Sources (as of 2026-09-12): Quarterly income statement (USD thousands); Reported versus estimated, last 8 quarters

Can Alnylam fund its RNAi pipeline without leaning on new debt?

The current balance sheet holds net cash, and recent operating cash flow has been positive, indicating substantial internal funding capacity. That cushion still depends on commercial cash generation keeping pace with research and commercialization spending.

Sources (as of 2026-09-12): Cash, investments and debt; Cash against market value; Operating cash flow by quarter (USD millions); Cash and short-term investments over time (USD millions)

What must happen before Alnylam can launch nucresiran for hATTR polyneuropathy?

Management’s timetable depends on favorable late-stage clinical results and regulatory approval. Until those gates are cleared, nucresiran remains a development program rather than a commercial contributor.

Sources (as of 2026-09-12): Management outlook — dated call excerpts; Business description

What is the ALNY stock price today?

The last price recorded on this page for Alnylam Pharmaceuticals, Inc. (ALNY) is $219.89, as of the Oct 5, 2026 trading session (source: Financial Modeling Prep (FMP) · quote). It is a provider snapshot, not a live exchange feed, so check a brokerage quote before you trade.

What is the ALNY price target?

The analyst consensus price target for Alnylam Pharmaceuticals, Inc. (ALNY) is $347.33 (range $256.00 to $455.00, median $334.00), per FMP data captured Oct 5, 2026. Targets are analyst opinions and change often; they are not a Stock Expert AI forecast.

Disclaimer: This content is for informational purposes only and does not constitute investment advice. Always do your own research and consult a financial advisor.

Research written by Codex (gpt-5.6-sol) on 2026-09-12. AI-authored analysis; source dates are shown with each answer. Editorial oversight is systemic, not page-by-page. Editorially accountable: Sedat ANAK, Founder and Editor-in-Chief.

Sources (as of 2026-09-12): Business description; Annual revenue and net result (USD millions); Quarterly income statement (USD thousands); Operating cash flow by quarter (USD millions)

Sources — records for every figure on this page (27 figures)

The 27 rows below are exactly the facts the evidence-backed sections of this page printed — the 10-second verdict, the MoonshotScore, price and market value, the five questions with their receipts, and the records behind this page. Known dates and sources are recorded on their own rows; an em dash or UNRECORDED tier preserves a stored observation without inventing either. The quarterly income statement is provider-standardized (FMP) under one row, and scale definitions — a 0-100 rating, the band ladder, the Piotroski 0–9 range — are fixed rather than measured. No number in those sections was generated by a model. The register does not cover quoted third-party headlines, the dated council readings, or the Frequently Asked Questions; each of those says where it came from where it stands.

"As of" is the date the value is true for where the source carries one — a quarter end, a filing date, a price close, the day the score was computed. A cached observation with no source date remains undated; the page publication date is not used as a substitute.

OFFICIAL — 1 fact from SEC filings and earnings calls

OFFICIAL facts used on this page
Fact IDFactValue as shownAs ofTierSource
id.hqSEC filing business address675 West Kendall Street, Henri A. Termeer Square, Cambridge, MA, 02142OFFICIALSEC EDGAR filer business address — The SEC filer business address. Our market-data provider separately lists "675 West Kendall Street, Cambridge, MA, 02142, US".

FMP — 22 facts from Financial Modeling Prep endpoint families

FMP facts used on this page
Fact IDFactValue as shownAs ofTierSource
px.lastLatest provided price$219.89FMPFinancial Modeling Prep (FMP) · quote — Dated to the US trading session the price belongs to, derived from the quote record's timestamp (weekend and pre-open reads roll back to the previous weekday; exchange holidays are not modelled). The record does not establish an exchange execution time. Retrieved 2026-10-06T06:34:30.819Z.
px.changeChange on the day+0.08%FMPFinancial Modeling Prep (FMP) · quote
px.mcapMarket capitalization$29.4BFMPFinancial Modeling Prep (FMP) quote — Provider market cap uses the share class it prices; a company with more than one class may show a larger total elsewhere. Market cap record date: 2026-10-06. Source capture time was not supplied. No share-count basis is inferred; this page preserves the reported amount instead of recalculating it from shares.
px.change_absChange on the day, in dollars+$0.17FMPFinancial Modeling Prep (FMP) · quote
fin.q_revenueRevenue, Q2 FY2026$1.29BFMPFinancial Modeling Prep (FMP) · income statement (quarterly)
px.range5252-week range$197.81–$495.55FMPFinancial Modeling Prep (FMP) quote
px.pePrice / earnings (trailing)36.05FMPFinancial Modeling Prep (FMP) · quote
px.volumeShares traded on the day1.28MFMPFinancial Modeling Prep (FMP) · quote
px.betaBeta0.3FMPFinancial Modeling Prep (FMP) company profile
id.ceoChief executiveYvonne L. GreenstreetFMPFinancial Modeling Prep (FMP) key executives (proxy-derived) — Titles and pay come from the company's proxy statement as our provider parsed it.
id.employeesEmployees2,500FMPFinancial Modeling Prep (FMP) company profile
fin.annualRevenue and net result by fiscal year4 fiscal years, FY2022 through FY2025: FY2022 revenue $0.00, net result $0.00; FY2023 revenue $0.00, net result $0.00; FY2024 revenue $0.00, net result $0.00; FY2025 revenue $0.00, net result $0.00FMPFinancial Modeling Prep (FMP), from the company's 10-K income statements
fin.gross_marginGross margin (trailing twelve months)79.7%FMPFinancial Modeling Prep (FMP) key-metrics-ttm + ratios-ttm — A ratio our provider could not compute is absent rather than shown as zero.
fin.q_tableQuarterly income statement4 quarters through Q2 FY2026FMPFinancial Modeling Prep (FMP) · income statement (quarterly), as filed
fin.cash_investmentsCash and short-term investments$0.00FMPFinancial Modeling Prep (FMP), from the company's balance sheet — Long-term investments are shown separately; their marketability is not established by the provider field. The cash and short-term investment balance does not establish unrestricted availability. Long-term investments are excluded and remain unclassified. Restrictions on cash and short-term investments require separate review. The market-value ratio is undefined when the reported amount is zero.
fin.total_debtTotal debt$0.00FMPFinancial Modeling Prep (FMP), from the company's balance sheet — Long-term investments are shown separately; their marketability is not established by the provider field. The cash and short-term investment balance does not establish unrestricted availability.
fin.price_to_bookPrice to book value21.64×FMPFinancial Modeling Prep (FMP) key-metrics-ttm + ratios-ttm — A ratio our provider could not compute is absent rather than shown as zero.
earn.ptStored analyst price targetslow $256.00 · high $455.00 · consensus $347.33 · median $334.00FMPFinancial Modeling Prep (FMP) · price-target consensus — Captured Oct 5, 2026 · Coverage not supplied
earn.pt_rangeAnalyst price target, low to high$256.00 – $455.00FMPFinancial Modeling Prep (FMP) · price-target consensus — Captured Oct 5, 2026 · Coverage not supplied
earn.pt_consensusConsensus analyst price target$347.33FMPFinancial Modeling Prep (FMP) · price-target consensus — Captured Oct 5, 2026 · Coverage not supplied
earn.pt_medianMedian analyst price target$334.00FMPFinancial Modeling Prep (FMP) · price-target consensus — Captured Oct 5, 2026 · Coverage not supplied
own.insidersInsider transactions via FMP29 transactions · 0 purchases, 5 sales, 24 other transactions · 11 identified insiders · of the newest 100 records, those within the last 180 days, newest dated Sep 19, 2026FMPFinancial Modeling Prep (FMP), carrying Form 4 transaction records — Purchases and sales use the reported transaction category. Other transactions include awards, exercises, gifts, withholding and unclassified activity; an acquisition or disposition alone is not a purchase or sale. These records do not establish intent.

UNRECORDED — 2 facts from stored observations whose source was not recorded

UNRECORDED facts used on this page
Fact IDFactValue as shownAs ofTierSource
earn.historyReported versus estimated, recent quartersEPS beat 5 of 8UNRECORDEDStored earnings-history observation — Captured 2026-09-30 · Expired observation
fin.scoresDistress and quality screensAltman Z 4.79 · Piotroski F 6UNRECORDEDStored financial-scores observation — Captured 2026-10-04 · Expired observation

OURS — 2 facts from Stock Expert AI's own score and rank

OURS facts used on this page
Fact IDFactValue as shownAs ofTierSource
ours.moonshotMoonshotScore v289 of 100 · Exceptional · pillars 96 / 59 / 41 / 100 / 28OURSStock Expert AI MoonshotScore v2 engine
ours.moonshot_changeMoonshotScore movement89 (stored snapshot Oct 5, 2026) → 89 (current publication computed Oct 6, 2026) (0)OURSStock Expert AI current score publication and immutable score snapshots — The current score publication is not yet represented in the immutable snapshot archive.
Published
Research standards
Methodology · Editorial policy · Corrections

Sources used for research written 2026-09-12

Historical evidence preserved with this analysis. Current figures are listed separately above.

EvidenceCaptured valueSource dateSource typeSource
Business description
Alnylam Pharmaceuticals, Inc. is a biopharmaceutical company primarily dedicated to the discovery, development, and commercialization of innovative therapeutic solutions leveraging ribonucleic acid interference (RNAi) technology. Its robust pipeline of RNAi-based treatments addresses a range of critical therapeutic areas, including inherited genetic disorders, cardio-metabolic conditions, hepatic infectious diseases, and central nervous system (CNS) and ocular disorders. Currently, Alnylam offers several approved therapies: ONPATTRO (patisiran) for adults suffering from polyneuropathy associated with hereditary transthyretin-mediated amyloidosis; GIVLAARI for adult patients with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for primary hyperoxaluria type 1 (PH1). Beyond its commercial portfolio, the company maintains an active development pipeline. Key investigational therapies include givosiran, aimed at adolescent patients with AHP; patisiran, being explored for transthyretin amyloidosis (ATTR) with cardiomyopathy; cemdisiran for complement-mediated disorders; ALN-AAT02 for AAT deficiency-associated liver disease; ALN-HBV02 for chronic hepatitis B virus infection; Zilebesiran for hypertension; and ALN-HSD for non-alcoholic steatohepatitis (NASH). Additionally, other candidates such as Fitusiran for hemophilia and bleeding disorders, Inclisiran for hypercholesterolemia, an expanded indication for lumasiran for advanced PH1 and recurrent kidney stones, and vutrisiran for ATTR amyloidosis (currently in Phase 3 clinical trials) are also progressing. Alnylam also engages in strategic alliances with other pharmaceutical leaders. Notable collaborations include those with Regeneron Pharmaceuticals, Inc., focused on discovering and developing RNAi therapeutics for ocular and CNS targets, and with Sanofi Genzyme for broader RNAi therapeutic development and commercialization efforts. Further licensing and partnership agreements are in place with entities such as Novartis AG, Vir Biotechnology, Inc., Dicerna Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., and PeptiDream, Inc. Established in 2002, Alnylam Pharmaceuticals maintains its corporate headquarters in Cambridge, Massachusetts.
2026-09-12FMPFinancial Modeling Prep (FMP) company profile
Annual revenue and net result (USD millions)
Captured record · 5 entries
  • FY2025 — R&D: $1.32B, Revenue: $3.71B, Period end: 2025-12-31, Net result: $313.75M
  • FY2024 — R&D: $1.13B, Revenue: $2.25B, Period end: 2024-12-31, Net result: -$278.16M
  • FY2023 — R&D: $1.00B, Revenue: $1.83B, Period end: 2023-12-31, Net result: -$440.24M
  • FY2022 — R&D: $883.02M, Revenue: $1.04B, Period end: 2022-12-31, Net result: -$1.13B
  • FY2021 — R&D: $792.16M, Revenue: $844.29M, Period end: 2021-12-31, Net result: -$852.82M
2025-12-31FMPFinancial Modeling Prep (FMP), from the company's 10-K income statements
Quarterly income statement (USD thousands)
Captured record · 8 entries
  • Quarter ended 2026-06-30 — EPS: $1.2 per share, R&D: $413.13M, SG&A: $347.92M, EPS basic: $1.23 per share, EPS basis: diluted, Revenue: $1.29B, EPS diluted: $1.2 per share, Net result: $164.49M, Gross profit: $992.69M, Operating result: $231.44M
  • Quarter ended 2026-03-31 — EPS: $1.51 per share, R&D: $364.87M, SG&A: $322.55M, EPS basic: $1.55 per share, EPS basis: diluted, Revenue: $1.17B, EPS diluted: $1.51 per share, Net result: $205.99M, Gross profit: $956.05M, Operating result: $268.64M
  • Quarter ended 2025-12-31 — EPS: $1.37 per share, R&D: $372.22M, SG&A: $325.37M, EPS basic: $1.41 per share, EPS basis: diluted, Revenue: $1.10B, EPS diluted: $1.37 per share, Net result: $186.42M, Gross profit: $829.31M, Operating result: $131.72M
  • Quarter ended 2025-09-30 — EPS: $1.84 per share, R&D: $358.81M, SG&A: $322.08M, EPS basic: $1.91 per share, EPS basis: diluted, Revenue: $1.25B, EPS diluted: $1.84 per share, Net result: $251.08M, Gross profit: $1.05B, Operating result: $367.98M
  • Quarter ended 2025-06-30 — EPS: -$0.51 per share, R&D: $323.62M, SG&A: $323.31M, EPS basic: -$0.51 per share, EPS basis: diluted, Revenue: $773.69M, EPS diluted: -$0.51 per share, Net result: -$66.28M, Gross profit: $630.74M, Operating result: -$16.20M
  • Quarter ended 2025-03-31 — EPS: -$0.44 per share, R&D: $265.12M, SG&A: $239.95M, EPS basic: -$0.44 per share, EPS basis: diluted, Revenue: $594.19M, EPS diluted: -$0.44 per share, Net result: -$57.48M, Gross profit: $523.15M, Operating result: $18.08M
  • Quarter ended 2024-12-31 — EPS: -$0.65 per share, R&D: $300.17M, SG&A: $295.34M, EPS basic: -$0.65 per share, EPS basis: diluted, Revenue: $593.17M, EPS diluted: -$0.65 per share, Net result: -$83.76M, Gross profit: $490.35M, Operating result: -$105.16M
  • Quarter ended 2024-09-30 — EPS: -$0.87 per share, R&D: $270.93M, SG&A: $220.99M, EPS basic: -$0.87 per share, EPS basis: diluted, Revenue: $500.92M, EPS diluted: -$0.87 per share, Net result: -$111.57M, Gross profit: $415.01M, Operating result: -$76.91M
2026-06-30FMPFinancial Modeling Prep (FMP), from the company's 10-Q and 10-K income statements
Operating cash flow by quarter (USD millions)
Captured record · 8 entries
  • Quarter ended 2026-06-30 — Capital expenditure: -$34.68M, Operating cash flow: $75.32M
  • Quarter ended 2026-03-31 — Capital expenditure: -$21.83M, Operating cash flow: $70.50M
  • Quarter ended 2025-12-31 — Capital expenditure: -$23.29M, Operating cash flow: $163.56M
  • Quarter ended 2025-09-30 — Capital expenditure: -$12.14M, Operating cash flow: $325.11M
  • Quarter ended 2025-06-30 — Capital expenditure: -$14.29M, Operating cash flow: $153.73M
  • Quarter ended 2025-03-31 — Capital expenditure: -$8.97M, Operating cash flow: -$118.31M
  • Quarter ended 2024-12-31 — Capital expenditure: -$9.09M, Operating cash flow: -$94.66M
  • Quarter ended 2024-09-30 — Capital expenditure: -$4.19M, Operating cash flow: $43.71M
2026-06-30FMPFinancial Modeling Prep (FMP), from the company's 10-Q cash-flow statements
Revenue by segment
GIVLAARI: $308.49M; ONPATTRO: $172.79M
2025-12-31FMPFinancial Modeling Prep (FMP) revenue segmentation, from the company's 10-K
Reported versus estimated, last 8 quarters
Captured record · 8 entries
  • Reported 2026-07-30 — EPS actual: $1.21 per share, EPS estimated: $1.63 per share, Revenue actual: $1.29B, Revenue estimated: $1.32B
  • Reported 2026-04-30 — EPS actual: $1.51 per share, EPS estimated: $0.872 per share, Revenue actual: $1.17B, Revenue estimated: $1.12B
  • Reported 2026-02-12 — EPS actual: $0.82 per share, EPS estimated: $1.16 per share, Revenue actual: $1.10B, Revenue estimated: $1.15B
  • Reported 2025-10-30 — EPS actual: $1.84 per share, EPS estimated: $0.561 per share, Revenue actual: $1.25B, Revenue estimated: $959.40M
  • Reported 2025-07-31 — EPS actual: -$0.51 per share, EPS estimated: -$0.54371 per share, Revenue actual: $773.69M, Revenue estimated: $662.87M
  • Reported 2025-05-01 — EPS actual: -$0.44 per share, EPS estimated: -$0.89002 per share, Revenue actual: $594.19M, Revenue estimated: $585.14M
  • Reported 2025-02-13 — EPS actual: -$0.65 per share, EPS estimated: -$0.62 per share, Revenue actual: $593.17M, Revenue estimated: $582.61M
  • Reported 2024-10-31 — EPS actual: -$0.87 per share, EPS estimated: -$0.91663 per share, Revenue actual: $500.92M, Revenue estimated: $532.91M
2026-07-30FMPFinancial Modeling Prep (FMP) earnings
Management outlook — dated call excerpts
Captured record · 1 entry
  • Call of 2026-07-30 — Quote: Additionally, in 2028, we anticipate the launch of nucresiran in hATTR polyneuropathy, assuming positive Phase III data and regulatory approval., Speaker: Pushkal Garg

Selected verbatim statements from the latest available call, dated by the transcript provider. Management expectations, not completed milestones or guarantees. Relative dates retain the speaker's wording.

2026-07-30OFFICIALCompany earnings call, transcript via Financial Modeling Prep (FMP)
Cash, investments and debt
Total debt: $1.27B; Liquidity basis: cash and short-term investments; Total liabilities: $4.20B; Cash and short-term investments: $3.31B; Cash and investments: $3.31B; Long-term investments: $0; Long-term investments classification: unclassified

Long-term investments are shown separately; their marketability is not established by the provider field. The cash and short-term investment balance does not establish unrestricted availability.

2026-06-30FMPFinancial Modeling Prep (FMP), from the company's balance sheet
Cash and investment components
Total basis: cash short and long-term investments; Total: $3.31B; Cash and short-term investments: $3.31B; Long-term investments: $0; Long-term investments classification: unclassified

Sums the balance sheet's cash and short-term investments with its long-term investments.; The long-term investment field does not establish marketability; the sum is not a measure of available liquidity.; These provider fields do not establish investment access restrictions or explain differences from third-party cash figures.

2026-06-30COMPUTEDComputed from the balance sheet
Cash and short-term investments over time (USD millions)
Captured record · 8 entries
  • 2026-06-30 — Amount: $3.31B, Cash basis: cash and short-term investments
  • 2026-03-31 — Amount: $3.01B, Cash basis: cash and short-term investments
  • 2025-12-31 — Amount: $2.91B, Cash basis: cash and short-term investments
  • 2025-09-30 — Amount: $2.72B, Cash basis: cash and short-term investments
  • 2025-06-30 — Amount: $2.86B, Cash basis: cash and short-term investments
  • 2025-03-31 — Amount: $2.63B, Cash basis: cash and short-term investments
  • 2024-12-31 — Amount: $2.69B, Cash basis: cash and short-term investments
  • 2024-09-30 — Amount: $2.78B, Cash basis: cash and short-term investments
2026-06-30FMPFinancial Modeling Prep (FMP), from the company's quarterly balance sheets
Cash against market value
As of: 2026-06-30; Cash basis: cash and short-term investments; Net cash: $2.04B; Total debt: $1.27B; Cash and investments: $3.31B

Price-based multiples captured at research time are not repeated here; the page shows each once, from current figures with their own dates. Cash is the latest reported cash and short-term investment balance; long-term investments are excluded. Market capitalization is the latest provider value.; The reported balance does not establish unrestricted availability or liquidation value.; The two are measured on different dates — the balance sheet is a quarter-end, the market cap is a recent close.; Debt is total debt as reported, including operating lease liabilities where the filer includes them.

2026-06-30COMPUTEDComputed from the balance sheet and the latest market capitalization
Trailing twelve-month ratio set
Quick ratio: 2.99; Current ratio: 3.05; Debt to equity: 0.94; Net margin: 16.8%; Gross margin: 79.7%; Operating margin: 20.8%; Return on assets: 14.5%; Return on equity: 93.6%

Price-based multiples captured at research time are not repeated here; the page shows each once, from current figures with their own dates. A ratio our provider could not compute is absent rather than shown as zero.

2026-09-12FMPFinancial Modeling Prep (FMP) key-metrics-ttm + ratios-ttm
Next earnings report
Date: 2026-10-29; EPS estimate: $1.77 per share; Revenue estimate: $1.43B

The date is our provider's estimate until the company confirms it.

2026-09-12FMPFinancial Modeling Prep (FMP) earnings calendar
Analyst revenue and earnings estimates (average)
Captured record · 4 entries
  • FY2027 — EPS average: $10.08 per share, Revenue average: $6.93B, Revenue low: $6.13B, Revenue high: $7.92B, Analysts (revenue): 20
  • FY2028 — EPS average: $12.51 per share, Revenue average: $8.29B, Revenue low: $6.63B, Revenue high: $9.95B, Analysts (revenue): 22
  • FY2029 — EPS average: $14.37 per share, Revenue average: $9.33B, Revenue low: $8.41B, Revenue high: $10.46B, Analysts (revenue): 14
  • FY2030 — EPS average: $16.1 per share, Revenue average: $10.55B, Revenue low: $9.51B, Revenue high: $11.83B, Analysts (revenue): 11
2026-09-12FMPFinancial Modeling Prep (FMP) analyst estimates
Sector / industry (provider taxonomy)
Healthcare / Biotechnology

The company's SEC filings classify it under SIC 2834 — Pharmaceutical Preparations.

2026-09-12FMPFinancial Modeling Prep (FMP) company profile
Data Sources & Methodology
Figures come from Financial Modeling Prep (FMP). If FMP has no figure for a ticker, a price or fundamental may come from a Yahoo Finance fallback, or a price from an Alpaca fallback. SEC EDGAR is used only for filing links and company identity details (legal name, address), never for figures. AI analysis by Stock Expert AI proprietary algorithms. Technical indicators via industry-standard calculations. Last updated: .
Data Provenance
Sources: Financial Modeling Prep (FMP) — Primary · Yahoo Finance — Fallback · Alpaca — Tertiary
Last fetched:
Cache TTL: Quote 5min · Profile 7d · Financials 7d · Insider 48h
How we use AI: Numbers are pulled directly from FMP & Yahoo Finance — our AI writes the analysis, it never edits the figures.
Data provided as-is for educational purposes. Not financial advice. Methodology

Data provided for informational purposes only.

ETFs that hold ALNY

Funds in our ETF coverage that list ALNY among the top 10 holdings on their fund page, largest weight first. Each weight is the fund's reported holding weight as of the date in its row.

ETFWeightHoldings as of
NestYield Dynamic Income ETF (EGGY)4.66%
Nuveen ESG Mid-Cap Growth (NUMG)3.52%
FIDELITY WOMENS LEADERSHIP ETF (FDWM)1.60%