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COMPASS Pathways plc (CMPS)

For informational purposes only. Not financial advice. Analysis by Sedat Aydin, Founder & Editor-in-Chief | AI-powered analysis. Data sourced from SEC filings and institutional-grade financial providers. Editorially reviewed. Not financial advice.

COMPASS Pathways plc (CMPS) trades at $5.63 with AI Score 48/100 (Weak). COMPASS Pathways plc is a mental health care company focused on developing psilocybin therapy. Market cap: 541M, Sector: Healthcare.

Last analyzed: Mar 15, 2026
COMPASS Pathways plc is a mental health care company focused on developing psilocybin therapy. Their lead product, COMP360, is in Phase II clinical trials for treatment-resistant depression and post-traumatic stress disorder.
48/100 AI Score Target $19.20 (+241.3%) MCap 541M Vol 904K

COMPASS Pathways plc (CMPS) Healthcare & Pipeline Overview

CEOKabir Kumar Nath
Employees166
HeadquartersLondon, GB
IPO Year2020

COMPASS Pathways plc, a UK-based mental health care company, is pioneering psilocybin therapy through its COMP360 program. Currently in Phase II clinical trials, COMP360 targets treatment-resistant depression and PTSD, positioning the company at the forefront of innovative mental health treatments within the broader healthcare sector.

Data Provenance | Financial Data Quantitative Analysis NASDAQ Analysis: Mar 15, 2026

Investment Thesis

COMPASS Pathways presents a high-risk, high-reward investment opportunity within the burgeoning field of psychedelic medicine. The company's primary value driver is the successful development and commercialization of COMP360 for treatment-resistant depression and PTSD. Positive Phase II clinical trial results provide initial validation, but Phase III trials and regulatory approval are critical milestones. Key catalysts include the progression of COMP360 through clinical trials, potential partnerships with pharmaceutical companies, and evolving regulatory landscape surrounding psilocybin. The company's market capitalization stands at $0.61 billion as of March 2026. However, the company's negative P/E ratio of -2.57 reflects its current lack of profitability. Investors should closely monitor clinical trial outcomes, regulatory developments, and the company's cash runway.

Based on FMP financials and quantitative analysis

Key Highlights

  • COMP360 is in Phase II clinical trials for treatment-resistant depression, indicating advancement in clinical development.
  • The company's market capitalization is $0.61 billion, reflecting investor valuation of its potential.
  • COMPASS Pathways operates in both the United Kingdom and the United States, expanding its market reach.
  • The company has 166 employees, indicating its operational scale.
  • The company has a negative P/E ratio of -2.57, reflecting a lack of current profitability.

Competitors & Peers

Strengths

  • Proprietary COMP360 psilocybin therapy.
  • Completed Phase IIb clinical trials for TRD.
  • Experienced management team.
  • Strong intellectual property portfolio.

Weaknesses

  • Limited revenue generation.
  • High research and development costs.
  • Regulatory uncertainty surrounding psilocybin.
  • Reliance on successful clinical trial outcomes.

Catalysts

  • Phase III clinical trial results for COMP360 in treatment-resistant depression.
  • Regulatory approval decisions for COMP360 from health authorities in the United States and Europe.
  • Expansion of clinical trials into new indications, such as anxiety disorders and addiction.
  • Strategic partnerships with pharmaceutical companies to accelerate development and commercialization.

Risks

  • Unfavorable clinical trial results for COMP360.
  • Regulatory delays or rejection of COMP360.
  • Competition from other mental health treatments.
  • High research and development costs.
  • Negative public perception of psilocybin.

Growth Opportunities

  • Expansion of COMP360 into new indications: COMPASS Pathways can expand the use of COMP360 beyond treatment-resistant depression and PTSD. This includes exploring its potential in other mental health conditions such as anxiety disorders, obsessive-compulsive disorder (OCD), and addiction. The market size for anxiety disorders alone is estimated to reach $14.7 billion by 2027, presenting a significant growth opportunity.
  • Partnerships with pharmaceutical companies: COMPASS Pathways can collaborate with established pharmaceutical companies to accelerate the development and commercialization of COMP360. These partnerships can provide access to funding, expertise, and distribution channels. The timeline for these partnerships is dependent on clinical trial progress and regulatory milestones.
  • Geographic expansion: COMPASS Pathways can expand its operations into new geographic markets beyond the United Kingdom and the United States. This includes targeting countries with favorable regulatory environments and unmet needs for mental health treatments. The global market for mental health treatments is estimated to reach $242.4 billion by 2027, offering substantial growth potential.
  • Development of digital therapeutics: COMPASS Pathways can integrate digital therapeutics into its treatment program to enhance patient engagement, monitor outcomes, and personalize care. Digital therapeutics can improve the accessibility and scalability of COMP360. The market for digital therapeutics is projected to reach $9.6 billion by 2025, presenting a synergistic growth opportunity.
  • Advocacy and education: COMPASS Pathways can engage in advocacy and education efforts to raise awareness about mental health conditions and the potential of psilocybin therapy. This includes collaborating with patient advocacy groups, healthcare professionals, and policymakers. Increased awareness and acceptance can drive demand for COMP360 and support favorable regulatory changes.

Opportunities

  • Expansion into new indications.
  • Partnerships with pharmaceutical companies.
  • Geographic expansion.
  • Favorable regulatory changes.

Threats

  • Competition from other mental health treatments.
  • Unfavorable clinical trial results.
  • Adverse regulatory decisions.
  • Negative public perception of psilocybin.

Competitive Advantages

  • Patented COMP360 formulation.
  • Clinical trial data demonstrating efficacy.
  • Regulatory expertise in navigating the approval process.
  • First-mover advantage in the psilocybin therapy market.

About CMPS

COMPASS Pathways plc, incorporated in 2020 and headquartered in London, United Kingdom, is a mental health care company operating primarily in the UK and the United States. The company is focused on developing innovative therapies for mental health disorders, particularly treatment-resistant depression (TRD) and post-traumatic stress disorder (PTSD). COMPASS Pathways' lead product, COMP360, is a proprietary formulation of psilocybin, administered in conjunction with psychological support. The company's approach involves a structured program designed to optimize the therapeutic effects of psilocybin. COMP360 has completed Phase IIb clinical trials for TRD, demonstrating promising results in reducing depressive symptoms. It is also currently in Phase II clinical trials for PTSD. COMPASS Pathways aims to address the unmet needs of patients suffering from mental health conditions by developing evidence-based, accessible, and scalable treatments. The company was formerly known as COMPASS Rx Limited and changed its name to COMPASS Pathways plc in August 2020, marking a pivotal shift towards its current focus on psilocybin therapy.

What They Do

  • Develops COMP360, a psilocybin therapy for mental health disorders.
  • Conducts clinical trials to evaluate the safety and efficacy of COMP360.
  • Focuses on treatment-resistant depression and post-traumatic stress disorder.
  • Administers COMP360 in conjunction with psychological support.
  • Aims to address unmet needs in mental health treatment.
  • Seeks regulatory approval for COMP360 from health authorities.
  • Works to make psilocybin therapy accessible and scalable.

Business Model

  • Develops and patents psilocybin-based therapies.
  • Conducts clinical trials to demonstrate efficacy and safety.
  • Seeks regulatory approval for its therapies.
  • Commercializes approved therapies through partnerships or direct sales.

Industry Context

COMPASS Pathways operates within the rapidly evolving mental health care industry, specifically targeting treatment-resistant depression and PTSD. The market for mental health treatments is substantial and growing, driven by increasing awareness, prevalence, and unmet needs. The company's focus on psilocybin therapy positions it within the emerging field of psychedelic medicine, which is gaining traction as a potential breakthrough approach for certain mental health conditions. Competitors include traditional pharmaceutical companies developing antidepressant medications, as well as other companies exploring psychedelic-assisted therapies. The regulatory landscape surrounding psychedelic substances is evolving, with increasing acceptance and regulatory pathways being established in certain jurisdictions.

Key Customers

  • Patients with treatment-resistant depression.
  • Patients with post-traumatic stress disorder.
  • Healthcare providers who administer COMP360.
  • Mental health clinics and hospitals.
AI Confidence: 82% Updated: Mar 15, 2026

CMPS Financials

CMPS Price Today & Live Chart

COMPASS Pathways plc (CMPS) stock price: $5.63 (+0.01, +0.09%)

CMPS Latest News

CMPS Analyst Consensus

Consensus Rating

Aggregated Buy/Hold/Sell recommendations from Benzinga, Yahoo Finance, and Finnhub for CMPS.

Price Targets

Consensus target: $19.20

CMPS MoonshotScore

48/100

What does this score mean?

The MoonshotScore rates CMPS's growth potential on a scale of 0-100 across multiple factors including innovation, market disruption, financial health, and momentum.

Classification

Sector Healthcare Industry Medical - Care Facilities

Competitors & Peers

Latest News

Latest COMPASS Pathways plc Analysis

Leadership: Kabir Kumar Nath

CEO

Kabir Kumar Nath serves as the Chief Executive Officer of COMPASS Pathways plc. His background includes extensive experience in the pharmaceutical and healthcare industries. Prior to joining COMPASS Pathways, Nath held leadership positions at various global pharmaceutical companies, where he focused on commercial strategy, market access, and business development. He has a proven track record of driving growth and innovation in the healthcare sector. Nath's expertise spans a wide range of therapeutic areas, including mental health.

Track Record: Since becoming CEO of COMPASS Pathways, Kabir Kumar Nath has overseen the advancement of COMP360 through clinical trials and has led the company's efforts to secure regulatory approval. He has also focused on building strategic partnerships and expanding the company's reach. Under his leadership, COMPASS Pathways has made significant progress in establishing itself as a leader in the field of psychedelic medicine.

COMPASS Pathways plc ADR Information Sponsored

An American Depositary Receipt (ADR) is a certificate representing shares of a foreign company that are held by a U.S. depositary bank. CMPS, as an ADR, allows U.S. investors to invest in COMPASS Pathways plc, a UK-based company, without the complexities of cross-border transactions. The ADR trades on a U.S. exchange and is denominated in U.S. dollars.

  • Home Market Ticker: London Stock Exchange (LSE), United Kingdom
  • ADR Level: 2
  • ADR Ratio: 1:1
Currency Risk: As an ADR, CMPS is subject to currency risk. The value of the ADR is affected by fluctuations in the exchange rate between the U.S. dollar and the British pound. If the pound weakens against the dollar, the value of the ADR may decrease, and vice versa. Investors may want to evaluate this currency risk when investing in CMPS.
Tax Implications: Dividends paid on CMPS ADRs are subject to foreign dividend withholding tax in the United Kingdom. The standard withholding tax rate is typically 20%, but this may be reduced depending on tax treaties between the U.S. and the UK. Investors should consult with a tax advisor to understand the specific tax implications of investing in CMPS ADRs.
Trading Hours: The London Stock Exchange (LSE) operates from 8:00 AM to 4:30 PM GMT. U.S. markets, such as NASDAQ, operate from 9:30 AM to 4:00 PM EST. This means there is an overlap in trading hours, but also periods when one market is open and the other is closed. Investors should be aware of these differences when trading CMPS ADRs.

What Investors Ask About COMPASS Pathways plc (CMPS) — Healthcare

What does COMPASS Pathways plc do?

COMPASS Pathways plc is a mental health care company focused on developing and commercializing psilocybin therapy for treatment-resistant depression and other mental health disorders. Their lead product, COMP360, is a proprietary formulation of psilocybin administered in conjunction with psychological support. The company conducts clinical trials to evaluate the safety and efficacy of COMP360 and seeks regulatory approval from health authorities. COMPASS Pathways aims to address the unmet needs of patients suffering from mental health conditions by providing innovative and evidence-based treatments.

What do analysts say about CMPS stock?

Analyst coverage of COMPASS Pathways (CMPS) is focused on the potential of its COMP360 psilocybin therapy and the evolving regulatory landscape for psychedelic medicine. Key valuation metrics include the company's market capitalization and cash runway. Growth considerations center on the successful completion of clinical trials, regulatory approvals, and commercialization efforts. Analyst consensus reflects both optimism and caution, given the inherent risks and uncertainties associated with drug development and regulatory pathways. The company's negative P/E ratio of -2.57 reflects its current lack of profitability.

What are the main risks for CMPS?

COMPASS Pathways faces several key risks, including the potential for unfavorable clinical trial results, regulatory delays or rejection of COMP360, and competition from other mental health treatments. The company also faces risks related to high research and development costs, regulatory uncertainty surrounding psilocybin, and negative public perception of psilocybin. Successful navigation of these risks is critical to the company's long-term success. The company's reliance on successful clinical trial outcomes makes it particularly vulnerable to setbacks in its development pipeline.

How does COMPASS Pathways plc manage patent expiration risks?

As a company focused on developing novel therapies, COMPASS Pathways manages patent expiration risks through a multi-faceted approach. This includes actively seeking patent protection for its COMP360 formulation, as well as for methods of use and manufacturing processes. The company also invests in research and development to create new and improved therapies that can be patented. Furthermore, COMPASS Pathways may pursue strategies such as data exclusivity and market exclusivity to extend the period of market protection for its products beyond the patent life.

What revenue streams does COMPASS Pathways plc have in healthcare?

Currently, COMPASS Pathways does not have significant revenue streams as it is primarily focused on research and development. The company's potential future revenue streams depend on the successful commercialization of COMP360. These revenue streams could include direct sales of COMP360 to healthcare providers, licensing agreements with pharmaceutical companies, and revenue from digital therapeutics integrated into the treatment program. The timing and magnitude of these revenue streams are contingent on clinical trial outcomes, regulatory approvals, and market adoption.

What are the key factors to evaluate for CMPS?

COMPASS Pathways plc (CMPS) currently holds an AI score of 48/100, indicating low score. Analysts target $19.20 (+241% from $5.63). Key strength: Proprietary COMP360 psilocybin therapy. Primary risk to monitor: Unfavorable clinical trial results for COMP360. This is not financial advice.

How frequently does CMPS data refresh on this page?

CMPS prices update in real time during U.S. market hours (9:30 AM-4:00 PM ET, weekdays). Fundamentals refresh after quarterly or annual filings. Analyst ratings and AI insights update daily. News is aggregated continuously from financial sources.

What has driven CMPS's recent stock price performance?

Recent price movement in COMPASS Pathways plc (CMPS) can be influenced by earnings results, analyst revisions, sector rotation, and broader market sentiment. The current analyst target of $19.20 implies 241% upside from here. Notable catalyst: Proprietary COMP360 psilocybin therapy. Check the News and Technical Analysis tabs for the latest drivers. Past performance does not predict future results.

Disclaimer: This content is for informational purposes only and does not constitute investment advice. Always do your own research and consult a financial advisor.

Official Resources

Analysis updated AI Score refreshed daily
Data Sources & Methodology
Market data powered by Financial Modeling Prep & Yahoo Finance. AI analysis by Stock Expert AI proprietary algorithms. Technical indicators via industry-standard calculations. Last updated: .

Data provided for informational purposes only.

Analysis Notes
  • Information is based on publicly available sources and may be subject to change.
  • Investment in pharmaceutical companies carries inherent risks, including clinical trial failures and regulatory setbacks.
Data Sources

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